Effect of Vitamin B_6 Deficiency on S-Adenosylhomocysteine Hydrolase Activity as a Target Point for Methionine Metabolic Regulation
スポンサーリンク
概要
- 論文の詳細を見る
The objective of this study was to clarify the relationship between the accumulation of S-adenosylhomocysteine (SAH) and the change in the SAH hydrolase activity in vitamin B_6 (B_6). Male Wistar rats were fed a control diet (control and pair-fed groups) or B_6-free diet (B_6-deficient group) for 5 wk. Although the SAH-synthetic activity of SAH hydrolase significantly increased in the B_6-deficient group, SAH-hydrolytic activity of SAH hydrolase showed no significant difference in the liver among the three groups. On the other hand, SAH hydrolase mRNA in the liver did not show any significant change. Thus, the accumulation of SAH would be due to the increased SAH-synthetic activity of SAH hydrolase. The disturbed methionine metabolism by B_6-deficiency, such as a significant increase of plasma homocysteine, might induce the activation of SAH hydrolase in the direction of SAH synthesis.
- 日本ビタミン学会の論文
著者
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Hayakawa Takashi
The United Graduate School of Agricultural Science, Gifu University
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Tsuge Haruhito
College Of Bioscience And Biotechnology Chubu University
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TSUGE Haruhito
The United Graduate School of Agricultural Science, Gifu University
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ISA Yasuka
The United Graduate School of Agricultural Science, Gifu University
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Isa Yasuka
The United Graduate School Of Agricultural Scienc:faculty Of Home Economics Gifu Women's Univer
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Tsuge Haruhito
The United Graduate School Of Agricultural Scienc:college Of Bioscience And Biotechnology Chubu Univ
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University 1-1 Yanagido Gifu Gifu 501-1193 J
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University
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