Increase in S-Adenosylhomocysteine Content and Its Effect on the S-Adenosylhomocysteine Hydrolase Activity under Transient High Plasma Homocysteine Levels in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The objective of this study was to examine how transient high plasma homocysteine (Hcy) levels affect the metabolism of Hcy, the activity and expression of S-ade-nosylhomocysteine (SAH) hydrolase which catalyzes both SAH hydrolysis and SAH synthesis. Wistar ST rats (males) were cannulated in the right jugular vein for intravenous infusion of physiological saline or DL-Hcy solutions (15 and 30mg/mL) for 1 h at 1.1mL/h/rat. The content of S-adenosylmethionine (SAM), SAH-synthetic activity of SAH hydrolase and the expression of SAH hydrolase mRNA in liver extracts showed no significant difference in the Hcy infused groups as compared to the Control group. On the other hand, the contents of hepatic SAH in the Hcy infused groups were dose-dependent and significantly higher than that of the Control group. Thus, this study showed that hepatic SAH increased without any increase in the SAH-synthetic activity and the expression of SAH hydrolase mRNA under transient high plasma Hcy levels after intravenous infusion of Hcy.
- 日本ビタミン学会の論文
著者
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Hayakawa Takashi
The United Graduate School of Agricultural Science, Gifu University
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Tsuge Haruhito
College Of Bioscience And Biotechnology Chubu University
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MISHIMA Tomoyuki
School of Health Science, Gifu University of Medical Science
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ISA Yasuka
The United Graduate School of Agricultural Science, Gifu University
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Isa Yasuka
The United Graduate School Of Agricultural Scienc:faculty Of Home Economics Gifu Women's Univer
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Mishima Tomoyuki
School Of Health Science Gifu University Of Medical Science 795-1 Nagamine Ichihiraga Seki Gifu 501-
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University 1-1 Yanagido Gifu Gifu 501-1193 J
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Mishima Tomoyuki
岐阜医療科学大学 保健科学部
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University
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