Molecular characterization of the PEX14 gene from the methylotrophic yeast Pichia methanolica(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
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概要
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In this study, we describe the molecular characterization of the PmPEX14 gene encoding the peroxisomal membrane protein from the methylotrophic yeast Pichia methanolica. The pex14Δ strain of P. methanolica lost its ability to grow on methanol and oleate but grew normally on glucose. Disruption of the PmPEX14 caused a decrease in the activities of peroxisomal methanol-metabolizing enzymes and mislocalization of those proteins into the cytosol and vacuole. Taken together, these findings show that PmPex14p has an essential physiological role in methanol metabolism in P. methanolica.
- 公益社団法人日本生物工学会の論文
著者
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NAKAGAWA Junichi
Department of Food Science and Technology, Tokyo University of Agriculture
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TOMIZUKA NOBORU
Department of Food Science and Technology, Faculty of Bioindustry, Tokyo University of Agriculture
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Tomizuka Noboru
National Institute of Bioscience and Human-Technology (NIBH)
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Nakagawa Tomoyuki
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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Ito Takashi
Department Of Chemistry School Of Science The University Of Tokyo
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HAYAKAWA Takashi
Faculty of Applied Biological Science, Gifu University
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Fujimura Shuki
Department Of Food Science And Technology Faculty Of Bioindustry Tokyo University Of Agriculture
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Matsufuji Yoshimi
Department Of Food Science And Technology Faculty Of Bioindustry Tokyo University Of Agriculture
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Nakagawa Tomoyuki
Faculty Of Applied Biological Science Gifu University
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Ozawa Shotaro
Department Of Food Science And Technology Faculty Of Bioindustry Tokyo University Of Agriculture
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Ito Daisuke
Faculty of Bioindustry, Tokyo University of Agriculture
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Matsufuji Yoshimi
Faculty of Applied Biological Sciences, Gifu University
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Nakagawa Junichi
Department Of Food Science And Technology Faculty Of Bioindustry Tokyo University Of Agriculture
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Hayakawa Takashi
Faculty Of Applied Biological Sciences Gifu University
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Matsufuji Yoshimi
Faculty Of Applied Biological Sciences Gifu University
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Ito Daisuke
Faculty Of Applied Biological Sciences Gifu University
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Fujimura Shuki
Department Of Food Science And Technology Faculty Of Bio-industry Tokyo University Of Agriculture Gr
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Ito Takashi
Department of Chemical Engineering, Graduate School of Engineering, Nagoya University
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Ito Takashi
Department of Food Science and Technology, Faculty of Bioindustry, Tokyo University of Agriculture
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ITO Takashi
Department of Advanced Materials Chemistry, Graduate School of Engineering, Yokohama National University
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