脳卒中易発症性高血圧自然発症ラット (SHRSP) の血圧, 脳卒中病変, 血管病変および寿命におよぼすChlorellaの影響

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From 5 weeks of age, stroke-prone spontaneously hypertensive rats (SHRSP) were fed a diet based on Chlorella (Chlorella vulgaris E-25) and were either observed until natural death or sacrificed at 29 weeks of age in order to examine the effects of the alga on blood pressure, incidence of stroke lesions, hypertensive vascular lesions and life-span. The results were as follows: 1) Elevation of blood pressure was depressed from the start of Chlorella feeding, and after 10 weeks of age the blood pressure remained unchanged at 210 to 230mmHg. 2) The average life-span of the Chlorella diet group was remarkably longer than that of the control group. 3) In the Chlorella diet group, depression of plasma renin activity (PRA), reduction of incidence of cerebral stroke lesions, lowering of incidence of hypertensive vascular lesions in the kidneys, testes and adrenals, and depression of decrease in the elastin content in the aorta were recognized. This group also showed fewer changes in electron microscopical findings in the mesenteric arteries. These results demonstrated that the PRA of SHRSP fed the Chlorella diet was just as low as that of normotensive rats (WKY), and that the effects resulted in the inhibition of vascular lesions, and lowering of the incidence of cerebral stroke lesions, thus extending the life-span.
社団法人日本栄養・食糧学会の論文