スダチ果皮中のフラボノイド配糖体の構造および血圧降下作用

概要

論文の詳細を見る
The structure of flavonoids in hot water extracts of sudachi (Citrus sudachi) peels were investigated. The physiological activity of the extracts was tested on stroke-prone spontaneously hypotensive rat (SHR-SP). The separation and purification of flavonoids were conducted by solvent extraction, precipitation by lead subacetate, gel filtration on TSK gel HW-40 F and column chromatography on silica gel. Six constituents were isolated, and their structures were hesperidin (1), neohesperidin (2), hesperetin-7-O-{[α-rhamnosy l (1→2)]-[α-rhamnosyl (1→6)]-β-glucose} (3), sudachiin A (4), 3, 8-di-C-glucosylapigenin (5) and 3, 8-di-C-glucosyldiosmetin (6) by UV, MS, 1H-NMR and 13C-NMR spectroscopy and sugar analysis. Among these compounds, 3, 5 and 6 were new flavonoid glycosides. Each component was intravenously injected in SHR-SP (1 mg/100g of body weight). Constituent 4 lowered blood pressure.
社団法人日本農芸化学会の論文