Intrauterine Growth Retardation(IUGR)に関する研究 : 妊娠SHRSP並びに食塩負荷妊娠SHRSPの胎盤血流量について(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
The present study was designed to investigate the diseases associated with hypertension in pregnant rats. The diseases were similar to the severe toxemia of pregnancy in human beings, led to IUGR (intrauterine growth retardation) of the fetus, and gave rise to the delivery of SFD (small for dates) infants. In order to explore the pathology of SFD infants, the placental blood flow of animal models having an SFD tendency was determined with tracer microspheres. As the result, the ratio of placental blood flow to uterine blood flow and that of placental blood flow to renal blood flow increased gradually with the progress of pregnancy. On any day after the 16th day of pregnancy, these values were highest in WKY (Wistar Kyoto rats), followed by SHRSP (stroke prone spontaneously hypertensive rats) and then by salt feeding SHRSP. These facts suggest that one of the etiologies of IUGR is a decrease of the placental blood flow.
近畿大学の論文
1981-09-25