ユズ果皮中のフラボノイド配糖体の構造および血圧降下作用

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An attempt was made to isolate hypotensive substances from a hot water extract of yuzu. Eight flavonoid glycosides were isolated by repeated chromatography and gel filtration after extraction with butanol and treatment with lead subacetate. Their structures were established by UV, MS, 1H-NMR and 13C-NMR spectroscopy, and sugar analysis to be 3, 8-di-C-glucosylapigenin (1), hesperidin (2), naringin (3), narirutin (4), homoeriodictiol 7-[2-O-α-rhamnosyl-β-glucose] (5), hesperetin 7-{[α-rhamnosyl(1→2)]-[α-rhamnosyl (1→6)]-β-glucose} (6), naringenin 7-{[α-rhamnosyl (1→2)]-[α-rhamnosyl (1→6)]-β-glucose} (7) and (-)-cis-3, 5, 7-trihydroxy-3-methoxyflavanone 7-[2-O-α-rhamnosyl-β-glucose] (8). Among these compounds, 7 and 8 were a new flavanone and dihydroflavonol glycoside, respectively. Each component was intravenously injected into SHR-SP rats (1.0mg/100g body weight), and a hypotensive effect was weakly present in only 7.
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