Regulation of CaV1.2 Current: Interaction With Intracellular Molecules
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概要
- 論文の詳細を見る
CaV1.2 (α1c) is a pore-forming subunit of the voltage-dependent L-type calcium channel and is expressed in many tissues. The β and α2/δ subunits are auxiliary subunits that affect the kinetics and the expression of CaV1.2. In addition to the β and α2/δ subunits, several molecules have been reported to be involved in the regulation of CaV1.2 current. Calmodulin, CaBP1 (calcium-binding protein-1), CaMKII (calcium/calmodulin-dependent protein kinase II), AKAPs (A-kinase anchoring proteins), phosphatases, Caveolin-3, β2-adrenergic receptor, PDZ domain proteins, sorcin, SNARE proteins, synaptotagmin, CSN5, RGK family, and AHNAK1 have all been reported to interact with CaV1.2 and the β subunit. This review focuses on the effect of these molecules on CaV1.2 current.
著者
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Tohse Noritsugu
Department Of Cellular Physiology And Signal Transduction Sapporo Medical University School Of Medic
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Kobayashi Takeshi
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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Fukao Mitsuhiro
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Yamada Yoichi
Department Of Cellular Physiology And Signal Transduction Sapporo Medical University School Of Medic
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Tsutsuura Masaaki
Department Of Cellular Physiology And Signal Transduction Sapporo Medical University School Of Medic
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Fukao Mitsuhiro
Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Japan
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