ラットにおけるピリドキシン-β-グルコシドの利用と腸管吸収

概要

論文の詳細を見る
Utilization of a chemically synthesized pyridoxine-β-glucoside by vitamin B_6-deficient rats was examined in terms of its effects on the urinary excretion of xanthurenic acid and on the activation of vitamin B_6-enzymes, glutamate-pyruvate transaminase and cysteine desulfhydrase. Oral administration of pyridoxine-β-glucoside (30 μg per animal per day) for 12 days has led to a complete restoration of the urinary excretion of xanthurenic acid to a normal level. The levels of the enzymic activities in liver and erythrocytes recovered with statistical significance (P<0.01) to those in the "positive" control rats administered with authentic pyridoxine. The "β-glucosidase" catalyzing hydrolysis of pyridoxine-β-glucoside was found in small intestine at a significant level, and to a somewhat lesser level, in liver and blood. It thus appears that pyridoxine-β-glucoside in vivo avails as vitamin B_6 by enzymic conversion to free pyridoxine either before or after absorption in small intestine. The post-absorptive conversion is supported by permeation of pyridoxine-β-glucoside into serosal side with everted sacs and by the high effectiveness as vitamin B_6 of intravenously injected pyridoxine-β-glucoside.
日本ビタミン学会の論文
1977-04-25