Eremothecium ashbyiiのリボフラビン生産に及ぼすメチルキサンチン類(テオブロミン, テオフィリン, カフェイン)の効果

概要

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Xanthine brought about a high riboflavin production, while caffeine showed a drastic inhibition of riboflavin production and growth of the microorganism. However, it was elucidated that caffeine inhibited directly riboflavin production and, as a result, the growth of this organism was inhibited. In non-growing cells, the same results as those observed in growing cells were obtained. It seems possible that the inhibition of caffeine is decreased competitively by xanthine. Methylxanthines (theophylline, theobromine and caffeine) were absorbed into cells, at a significantly slower rate than xanthine during non-growing cell incubation and their ultraviolet absorption spectra were not changed with the incubation. Furthermore, the addition of xanthine and caffeine brought about the noticeable enhancement of the GTP pool and a marked shift towards ATP in the intracellular adenosine nucleotide pool at 18h after incubation.
1973-07-25