酵母によるアントラニル酸よりトリプトファンの醗酵生産 : (第4報) 金属イオンの影響について

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In a series of our study on the medium composition appropriate for the industrial production of tryptophan by a strain of Hansenula, the effects upon growth and tryptophan production of some metal salts, which appear in the Burkholder's prescription, were investigated. Shaken cultures in the basal and modified basal media were conducted at 27℃ for 5 days. It was found that the optimal concentration range of MgSO_4.7H_2O with regard to growth as well as to tryptophan production was 0.3〜1.0g/l. Regarding ferrous salt, optimal concentrations (as FeSO_4.7H_2O) were ca. 10mg/l for tryptophan production and 30〜100 mg/l for growth. A conspicuous feature was observed with the effect of zinc salt which showed, in a diagram of production versus concentration, a seep peak at 1 mg (as ZnSO_4.7H_2O)/l, althrough no significant effect upon growth was observed there.Inhibiting action of Co^<++> upon growth and tryptophan production was shown to be antagonized by Fe^<++>.
社団法人日本生物工学会の論文
1963-02-15