有機金属化合物の抗菌性 : (第2報)トリフェニル鉛アセテートおよびトリプロピル錫アセテートの抗菌スペクトルならびに抗菌機作について

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Organometallic compounds are generally used as agricultural chemicals and industrial antiseptics.The relationship between the chemical structure of triphenyl lead carboxylates and its antimicrobial activity was previously reported by the authors.In this paper, the antimicrobial activity of triphenyl lead acetate (TPLA) and tripropyl tin acetate (TPTA) was investigated against yeast (7 strains), mold (10 strains) and bacteria (4 strains), and experiments have been carried out to elucidate the modes of actions of TPLA and TPTA on E. coli K-12 and B. subtilis var. niger.The results obtained were as follows;1) The growth of all the strains tested was completely inhibited by TPLA and TPTA at a very low concentration (2〜25 μg/ml) 48 hours after the inoculation.2) Respiration of E. coli K-12 was not inhibited by TPLA and TPTA at 6 μg/ml.3) The incorporations of ^<14>C-chlorella amino acids into the cell pool fraction and into the protein fraction of E. coli K-12 were inhibited by TPLA and TPTA at 6 μg/ml.4) About 70% of the incorporaion of ^<14>C-adenine into the DNA and RNA fractions of E. coli K-12 was inhibited by TPLA and TPTA at 6 μg/ml.5) The incorporation of ^<14>C-glucosamine into the cell wall fraction of B. subtilis var. niger was not inhibited by TPLA and TPTA at 4 μg/ml.From these results, it may be concluded that TPLA and TPTA inhibit the biosyntheses of the DNA and RNA of E. coli K-12 as the primary sites of the inhibition.
社団法人日本生物工学会の論文
1971-01-25

有機金属化合物の抗菌性 : (第2報)トリフェニル鉛アセテートおよびトリプロピル錫アセテートの抗菌スペクトルならびに抗菌機作について

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