プロピレンオキシサイドの熱感受性, 熱耐性型胞子に対する殺菌効果

概要

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The chenge in the resistance of bacterial spores to propylene oxide (PO) was investigated using the heat-sensitive and heat-resistant spores of Bacillus subtilis var. niger.The hydrogen-form spores (H-form), which were heat-sensitive and prepared by mixing untreated spores in tryptone broth ajusted to pH 1.1,were about five times as sensitive as the untreated spores to PO, especially in a gaseous state. The H-form spores easily returned to a heat-resistant form (Ca-form) after treatment with a calcium acetate solution (pH 9.7). The Ca-form spores had the same resistance as the untreated spores to liquid PO, but were more sensitive to gaseous PO than were the untreated spores.When the relative humidity (RH) of he atmosphere in the sterilizing chamber was equal to the equilibrium RH of the spores, PO was able to kill the H-form spores to a high degree in the lower RH atmosphere, but unable to kill any form of spores in a dry atmosphere (RH 0%).It was estimated that the H-form spores gained no new receptor sites against PO, because the concentration indices of gaseous PO were the same for all forms of spores.
社団法人日本生物工学会の論文
1973-11-25