(3-トリアルキル錫)プロピルトリメチルアンモニウムアイオダイドの抗菌機作 : 有機金属化合物の抗菌性(第7報)

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The authors have recently reported a series of organometallic derivatives of group IV_b elements, R_3MX (where M=Pb, Sn). In a previous paper, it was reported that the polarographic behavior of trialkyl tin chlorides and their antimicrobial activites had been investigated. For this paper, the syntheses of (3-triethyl tin) propyltrimethyl ammonium iodide (ETQ), (3-tripropyl tin) propyltrimethyl ammonium iodide (PTQ) and (3-tributyl tin) propyltrimethyl ammonium iodide (BTQ) and their antimicrobial activities against E. coli were investigated.The modes of action of PTQ, tripropyl tin chloride (TPTC), lauryltrimethyl ammonium bromide (LTAB), and a combination of TPTC and LTAB against E. coli and B. subtilis var. niger were studied with respect to their chemical structure and the following results were obtained.1) PTQ was only slightly able to inhibit permeability and protein synthesis, and inhibited ribonucleic acid synthesis, deoxyribonucleic acid synthesis, and the respiration of E. coli in some measure, but markedly inhibited cell wall synthesis of B. subtilis var. niger.2) The antimicrobial activity of PTQ was remarkably enhanced at pH values around neutrality.3) The antimicrobial activities of PTQ and LTAB were not reversed, but TPTC was reversed to a considerable extent by cysteine.4) TPTC and a combinatin of TPTC and LTAB inhibited the snytheses of ribonucleic acid and deoxyribonucleic acid of E. coli as the primary action.5) LTAB inhibited the respiration of E. coli as the primary action.
社団法人日本生物工学会の論文
1973-11-25

(3-トリアルキル錫)プロピルトリメチルアンモニウムアイオダイドの抗菌機作 : 有機金属化合物の抗菌性(第7報)

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