有機金属化合物の抗菌性 : (第3報)トリフェニル鉛アセテートとラウリルトリメチルアンモニウムブロマイドの相乗機作について

概要

論文の詳細を見る
In a previous paper, it was reported that triphenyl lead acetate (TPLA) and tripropyl tin acetate (TPTA) inhibited the synthesis of DNA and RNA of Escherichia coli as the primary site of the inhibition. Combination effect of TPLA and lauryltrimethyl ammonium bromide (LTAB) was tested against seven strains ; Candida albicans, Aspergillus niger, Rhizopus nigricans, Tric- hoderma viride, Fusarium moniliforme, E.coli and Bacillus subtilis var niger. Striking growth inhibitory effects against all strains were observed by the combination of 3〜20μg/ml of LTAB and 0.4〜1.0μg/ml of TPLA. The mode of the synergistic effect of TPLA and LTAB was investigated and the following results were obtained : 1. The combination of TPLA and LTAB was only slightly able to inhibit the respiration, permeability, protein synthesis, ribonucleic acid synthesis, and cell wall synthesis, but markedly inhibit deoxyribonucleic add synthesis of E.coli. 2. The uptake of ^3H-TPLA into the cell pool fraction and the ethanol insoluble fraction of Saccharomyces sake was not markedly increased by the addition of 4μg/ml of LTAB. On the basis of these results, it seemed reasonable to assume that deoxyribonucleic acid synthesis is the primary site of growth inhibition by the synergistic action of TPLA and LTAB.
1972-01-25