有機金属化合物の抗菌性 : (第4報)トリプロピル錫およびトリブチル錫イソカルボン酸エステルの抗菌性について

概要

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Organometallic compounds have been shown to be highly effective agents as agricultural chemicals and industrial antiseptics. The relationship between the chemical structure of triphenyl lead iso-carboxylate and its antimicrobial activity has been previously reported by the authors. In this paper, the antimicrobial actions of tripropyl tin iso-carboxylates (13 compounds) and tributyl tin iso-carboxylates (13 compounds) on microbes (6 strains) were studied with respect to their chemical structure ; the following results were obtained. The growth of all the strains tested was completely inhibited by tripropyl tin iso-carboxylates and tributyl tin iso-carboxylates at very low concentrations (1.0-7.5μg/ml) for 15 days at 30℃. The antimicrobial activities of tripropyl tin iso-carboxylates and tributyl tin iso-carboxylates were affected by the carbon number of their acyl groups ; the activities were generally increased with a decrease in the carbon number of the main and side chains of their acyl groups. The activities of branched-chain compounds were affected by the position of the branches.
社団法人日本生物工学会の論文