トリフェニル錫アセテートおよびトリプロピル錫フェニルエーテルの抗菌機作 : 有機金属化合物の抗菌性(第5報)

概要

論文の詳細を見る
In a previous paper, it was reported that triphenyl lead acetate (TPLA) and tripropyl tin acetate (TPrTA) inhibited the synthesis of DNA and RNA of E.coli as the primary aciton.In this report, the mode of actions of triphenyl tin acetate (TPTA) and tripropyl tin phenyl ether (TPTPE) against E. coli and B. subtilis var. niger were investigated and the following results were obtained.1) Both TPTA and TPTPE were only slightly able to inhibit the respiraton, permeability, protein synthesis and cell wall synthesis, but markedly inhibit ribonucleic acid synthesis and deoxyribonucleic acid synthesis of E.coli.2) The growth inhibiton of E. coli by tripropyl tin phenylthioether (TPTSP) was not observed.3) The antimicrobial action of TPTA was reversed by cysteine and 2-mercaptoethanol.4) The enzyme activity of alcohol dehydrogenase from baker's yeast was not inhibited by TPTSP and TPTPE plus 2-mercaptoethanol, and it was markedly inhibited by TPTPE and TPTA.On the basis of these results, it may be concluded that TPTA and TPTPE inhibited the biosynthesis of the deoxyribonucleic acid and ribonucleic acid of E. coli as the primary acition, and the active sites of these tin and lead compounds of the type R_3MX were, respectively, metal protions of R_3M molecules.
社団法人日本生物工学会の論文
1973-03-25