スタフィロマイシン生産の生理的研究 : (第2報)生産誘導因子の生成について

概要

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In cultures of Streptomyces virginiae, the phase of staphylomycin production, which lasted for a short period, lay within the growing phase. A rapid lowering of the production rate occurred before cessation of growth suggested the instability of staphylomycin-synthesizing system. Results of replacement culture experiments indicated that a substance (denoted as IM) effective in inducing staphylomycin-synthesizing activity was formed just prior to the initiation of staphylomycin production. A method for estimating the potency of IM was established, which consisted in measuring staphylomycin production by young cells after being induced by an adequately diluted sample containing IM. IM formed was mostly secreted and found in the cultuer filtrate. It was not consumed in the course of staphylomycin production, implying that IM might not be one of the precursors of staphylomycin. From the pattern of product inhibition of staphylomycin synthesis, it was inferred that staphylomycin inhibited not only formation of IM but aloso the action of IM in inducing staphylomycin-synthesizing activity.
社団法人日本生物工学会の論文
1971-07-25