Antimicrobial Activity of a Compound Isolated from an Oil-Macerated Garlic Extract

概要

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A compound showing antimicrobial activity was isolated from an oil-macerated garlic extract by silica gel column chromatography and preparative TLC. On basis of the results of NMR and MS analyses, it was identified as Z-4,5,9-trithiadeca-1,6-diene-9-oxide (Z-10-devinylajoene ; Z-10-DA). Z-10-DA exhibited a broad spectrum of antimicrobial activity against such microorganisms as grampositive and gram-negative bacteria and yeasts. The antimicrobial activity of Z-10-DA was comparable to that of Z-ajoene, but was superior to that of E-ajoene. Z-10-DA and Z-ajoene are different in respect of substitution of the allyl group by the methyl group flanking a sulfinyl group. This result suggests that substitution by the methyl group would also be effective for the inhibition of microbial growth.
社団法人日本農芸化学会の論文
1998-05-23