Inhibitory Effects of Persimmon (Diospyros kaki) Extract and Related Polyphenol Compounds on Growth of Human Lymphoid Leukemia Cells

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概要

• 論文の詳細を見る

• We have investigated the effects of persimmon (Diospyros kaki) extract (PS) and related polyphenol compounds such as catechin (C), epicatechin (EC), epicatechingallate (ECG), epigallocatechin (EGC), and epigallocatechingallate (EGCG) on the growth of human lymphoid leukemia Molt 4B cells. We found that PS, ECG, EGC, and EGCG strongly inhibited the growth of the cells in a dose-dependent manner, while C and EC inhibited the growth of the cells only moderately. Ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, was inhibited by 10-20% by these polyphenol compounds. The morphology of the Molt 4B cells indicated severe damage 3 days after treatment with PS, ECG, EGC, and EGCG. Irregular shape of the cells and DNA fragmentation were observed in PS, ECG, EGC, or EGCG-treated cells. These results suggest that PS, ECG, EGC, and EGCG induce apoptosis (programmed cell death) of Molt 4B cells.

• 1997-07-23

著者

• KATSUZAKI Hirotaka

  Faculty of Bioresources, Mie University

• Imai K

  Faculty Of Bio-resources Mie University

• Imai Kunio

  Faculty Of Bioresources Mie University

• Hirata Hitoshi

  Department Of Orthopaedic Surgery Mie University Faculty Of Medicine

• ACHIWA Yumiko

  Faculty of Obsterics and Gynecology, School of Medicine, Fujita Health University

• Achiwa Yumiko

  Faculty Of Bioresource Mie University

• KOMIYA Takashi

  Faculty of Bioresources, Mie University

• Komiya T

  Mie Univ. Mie Jpn

• Komiya T

  Mie Univ. Mie

• Hibasami H

  Mie Univ. Mie Jpn

• HIBASAMI Hiroshige

  College of Medical Science, Mie University

• Komiya Takashi

  Faculty Of Bio-resources Mie University

• Katsuzaki H

  Faculty Of Bio-resources Mie University

• Imai Kunio

  Faculty Of Bio-resources Mie University

• IMAI Kunio

  Faculties of Bioresources, Mie University

• Katsuzaki Hirotaka

  Faculty of Bio-resources, Mie University

• KOMIYA Takashi

  Faculties of Bioresource, Mie University

• IMAI Kunio

  Faculties of Bioresource, Mie University

• KATSUZAKI Hirotaka

  Faculties of Bioresource, Mie University

• ACHIWA Yumiko

  Faculties of Bioresource, Mie University

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