Effect of Oleanolic and Ursolic Acids Isolated from Loquat (Eriobotrya) on the Growth of Human Lymphoid Leukemia Cells.

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概要

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• We have identified two triterpene carboxylic acids of oleanolic acid and ursolic acid isolated from the leaves of loquat (<I>Eriobotrya</I>) by NMR spectroscopy. We have investigated the effects of oleanolic acid and ursolic acid on the growth of lymphoid leukemia Molt 4B cells and obtained results in which both compounds inhibited the proliferation of Molt 4B cells. In an <I>in vitro </I>experiment, ursolic acid inhibited ornithine decarboxylase (ODC) activity by 25.9% and 39.7% at the concentrations of 1 mM and 2 mM, respectively, while oleanolic acid inhibited ODC activity to a lesser extent than did ursolic acid. Both compounds slightly suppressed <I>S</I>-adenosylmethionine decarboxylase (AdoMetDC) activity. Polyamine contents were decreased in these compound-treated cells. These findings demonstrate that growth suppression of human Iymphoid Molt 4B cells by ursolic acid and oleanolic acid may result from the depletion of polyamines caused by the inhibition of ODC and AdoMetDC activities.

• 社団法人 日本食品科学工学会の論文

著者

• Achiwa Yumiko

  Faculty Of Bioresource Mie University

• Yamada Tetsuya

  Faculty Of Bioresources Mie University

• Komiya Takashi

  Faculty Of Bio-resources Mie University

• IMAI Kunio

  Faculties of Bioresources, Mie University

• Katsuzaki Hirotaka

  Faculty of Bio-resources, Mie University

• SAKURAI Shinobu

  Medicine, Mie University

• URAKAWA Kayako

  Medicine, Mie University

• OHNISHI Kazuko

  Medicine, Mie University

• ADACHI Takuo

  Faculties of Bioresource, Mie University

• HIBASAMI Hiroshige

  Medicine, Mie University

• KOMIYA Takashi

  Faculties of Bioresource, Mie University

• IMAI Kunio

  Faculties of Bioresource, Mie University

• YAMADA Tetsuya

  Faculties of Bioresource, Mie University

• KATSUZAKI Hirotaka

  Faculties of Bioresource, Mie University

• ACHIWA Yumiko

  Faculties of Bioresource, Mie University

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