Enin Isolated from Skin of Red Grape (Vitris vinifera) Induces Apoptosis in Human Lymphoid Leukemia Molt 4B Cells

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概要

• 論文の詳細を見る

• We have investigated the effect of extract prepared from skin of red grape (Vitris vinifera) on the growth of human lymphoid leukemia Molt 4B cells. It was found that the extract obtained by extraction with butanol suppressed the growth of Molt 4B cells. Fraction IV obtained by separation with HPLC inhibited the growth of the Molt 4B cells by 86% at the concentration of 600 μM. We determined the structure of compound contained in Fraction IV and identified it as enin, a kind of anthocyanin, by 1H- and 13C-NMR. The enin-treated cells clearly exhibited morphological changes, indicating the blebbing and chromatin condensation which are characteristic of apoptosis. Characteristic oligonucleosomal-sized DNA fragments were observed in the enin-treated cells. These findings suggest that the suppression by enin of growth of Molt 4B cells results from the induction of apoptosis by this compound.

• 社団法人　日本食品科学工学会の論文
• 2001-05-01

著者

• Nakagawa Masako

  Faculty of Pharmaceutical Sciences, Chiba University

• HIBASAMI Hiroshige

  Faculty of Medicine, Mie University

• Hibasami Hiroshige

  Faculty Of Medicine Mie University

• KATSUZAKI Hirotaka

  Faculty of Bioresources, Mie University

• Imai K

  Faculty Of Bio-resources Mie University

• Imai Kunio

  Mie Univ. Tsu Jpn

• Imai Kunio

  Laboratory Of Organic Chemistry Faculty Of Agriculture Nagoya University

• Imai Kunio

  Faculty Of Bioresources Mie University

• Hirata Hitoshi

  Department Of Orthopaedic Surgery Mie University Faculty Of Medicine

• KOMIYA Takashi

  Faculty of Bioresources, Mie University

• Komiya T

  Mie Univ. Mie Jpn

• Komiya T

  Mie Univ. Mie

• Hibasami H

  Mie Univ. Mie Jpn

• Nakagawa Masako

  Faculty Of Medicine Mie University

• MOTEKI Hiroyuki

  International Flavors & Fragrances (Japan) Ltd.

• OHWAKI Shinji

  Faculty of Bioresource, Mie University

• ISHII Yaeko

  Faculty of Medicine, Mie University

• Ishii Yaeko

  Faculty Of Medicine Mie University

• Ohwaki Shinji

  Faculty Of Bioresource Mie University

• Moteki Hiroyuki

  International Flavors & Fragrances (japan) Ltd.

• Komiya Takashi

  Faculty Of Bio-resources Mie University

• Katsuzaki H

  Faculty Of Bio-resources Mie University

• Imai Kunio

  Faculty Of Bio-resources Mie University

• IMAI Kunio

  Faculties of Bioresources, Mie University

• Katsuzaki Hirotaka

  Faculty of Bio-resources, Mie University

• Hibasami Hiroshige

  Faculties of Medicine, Mie University

• KOMIYA Takashi

  Faculties of Bioresource, Mie University

• IMAI Kunio

  Faculties of Bioresource, Mie University

• KATSUZAKI Hirotaka

  Faculties of Bioresource, Mie University

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