Regulation of the Phosphatidylinositol 3-Kinase-Akt and the Mitogen-Activated Protein Kinase Pathways by Ursolic Acid in Human Endometrial Cancer Cells
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概要
- 論文の詳細を見る
The phosphatidylinositol 3-Kinase-Akt (PI3K-Akt) pathway and the mitogen activated protein kinase (MAPK) pathway are important in the development and proliferation of various human cancers. It has been found recently that ursolic acid treatment affects growth and apoptosis in cancer cells. We sought to determine whether prominent signaling pathways, including the PI3K-Akt pathway and the MAPK (JNK, P38, and P44/42) pathway mediate these effects. Endometrial cancer cells often have high levels of phosphorylated Akt seen in conjunction with a PTEN mutation or deletion. Elevation in Akt protects the cancer cell from apoptosis. Ursolic acid treatment moderately decreased PI3K levels in SNG-II cells. Treatment also decreased phospho-Akt and phospho-P44/42 in a dose- and time-dependent fashion, dramatically in SNG-II cells and moderately in HEC108 cells. This effect was most pronounced following treatment with 50 μm ursolic acid for 72 h. Our study found inhibition of both the PI3K-Akt pathway and the MAPK pathway in two endometrial cancer cell lines, SNG-II and the poorly differentiated HEC108 cell line.
- 社団法人 日本農芸化学会の論文
- 2007-01-23
著者
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Udagawa Yasuhiro
Department Of Obstetrics And Gynecology Fujita Health University
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Hasegawa Kiyoshi
Department Of Obstetrics And Gynecology Fujita Health University
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ACHIWA Yumiko
Department of Obstetrics and Gynecology, Fujita Health University School of Medicine
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ACHIWA Yumiko
Faculty of Obsterics and Gynecology, School of Medicine, Fujita Health University
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HASEGAWA Kiyoshi
Faculty of Obsterics and Gynecology, School of Medicine, Fujita Health University
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UDAGAWA Yasuhiro
Faculty of Obsterics and Gynecology, School of Medicine, Fujita Health University
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Achiwa Yumiko
Faculty Of Bioresource Mie University
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Achiwa Yumiko
Department Of Obstetrics And Gynecology Fujita Health University School Of Medicine
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Udagawa Yasuhiro
Fujita Health University
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Udagawa Y
Fujita Health University
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ACHIWA Yumiko
Faculties of Bioresource, Mie University
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- Regulation of the Phosphatidylinositol 3-Kinase-Akt and the Mitogen-Activated Protein Kinase Pathways by Ursolic Acid in Human Endometrial Cancer Cells