Antimutagenic Effects of Ajoene, an Organosulfur Compound Derived from Garlic
スポンサーリンク
概要
- 論文の詳細を見る
The antimutagenic effects of ajoene, which is an organosulfur compound derived from garlic, were investigated by the Ames test. Ajoene inhibited mutagenesis induced by both benzo[a]pyrene (B[a]P) and 4-nitro-1,2-phenylenediamine (NPD) in a dose-dependent manner. In particular, NPD-induced mutagenesis was more effectively suppressed by ajoene than the B[a]P-induced type. Furthermore, the inhibition of mutagenesis by ajoene was more effective for transition-type mutations than for the frame shift type. HPLC analysis of B[a]P metabolism in the presence of the rat liver microsomal fraction (S-9) showed that ajoene dose-dependently inhibited the metabolic activation of B[a]P. This suggests that ajoene affected the metabolic enzymes in the S-9 fraction.
- 社団法人日本農芸化学会の論文
- 1996-12-23
著者
-
YOSHIDA Hiroko
Division of Food and Nutrition, Nakamura Gakuen Junior College
-
FUKUDA Hiroyuki
Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
Suzuki Atsushi
Biodevelopment Division Central Institute Nagoya Seiraku Co. Ltd.
-
Suzuki Atsushi
Department Of Applied Biological Chemistry Faculty Of Agriculture University Of Niigata
-
Suzuki Atsushi
Synthetic Crystal Research Laboratory Faculty Of Engineering Nagoya University
-
Suzuki Atsushi
Department Of Pathology Obstetrics And Gynecology Keio University School Of Medicine
-
Suzuki Atsushi
Basic Research Department Prima Meat Packers Co. Ltd.
-
Suzuki Atsushi
Department Of Applied Biochemistry Faculty Of Agriculture University Of Niigata
-
Suzuki A
Department Of Obstetrics And Gynecology Keio University School Of Medicine
-
Suzuki A
Department Of Applied Biological Chemistry Faculty Of Agriculture University Of Niigata
-
NAGANAWA Rie
Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
ISHIKAWA Keiko
Bio Development Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
NAGANAWA Rie
Bio Development Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
YOSHIDA Hisae
Bio Development Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
IWATA Nami
Bio Development Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
FUKUDA Hiroyuki
Bio Development Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
FUJINO Tsuchiyoshi
Bio Development Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
SUZUKI Atsushi
Bio Development Division, Central Institute, Nagoya Seiraku Co., Ltd.
-
Iwata N
Drug Discovery Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
-
Naganawa Rie
Biodevelopment Division Central Institute Nagoya Seiraku Co. Ltd.
-
Yoshida H
Division Of Food And Nutrition Nakamura Gakuen Junior College
-
Ishikawa K
Biodevelopment Division Central Institute Nagoya Seiraku Co. Ltd.
-
Yoshida Hiromi
Faculty Of Nutrition Kobe Gakuin University
-
Fukuda Hiroyuki
Biodevelopment Division Central Institute Nagoya Seiraku Co. Ltd.
-
Fukuda H
Choko Shoyu Miso Co‐op. Nagasaki Jpn
-
Fujino Tsuchiyoshi
Biodevelopment Division Central Institute Nagoya Seiraku Co. Ltd.
-
Fujino Tsuchiyoshi
Bio Development Division Nagoya Seiraku Co. Ltd.
関連論文
- Layer Structure of Antiferroelectric Liquid Crystal MHPOBC Studied by X-Ray Diffraction
- Dielectric Dispersion in the Antiferroelectric Liquid Crystal MHPOBC
- Effect of a Polyimide Coat on the Layer Structure in a Surface-Stabilized Ferroelectric Liquid Crystal Cell
- Effects of High Pressure Treatment on the Ultrastructure and Solubilization of Isolated Myofibrils(Food & Nutrition)
- Structures and Biosynthesis of Aflastatins: Novel Inhibitors of Aflatoxin Production by Aspergillus parasiticus
- Biological and therapeutic significance of MUC1 with sialoglycans in clear cell adenocarcinoma of the ovary
- A case of pulmonary type of ovarian small cell carcinoma
- Effect of Tea Catechins on Cellular Lipid Peroxidation and Cytotoxicity in HepG2 Cells(Food & Nutrition Science)
- Rotihibins, Novel Plant Growth Regulators from Streptomyces graminofaciens
- Reduction of the Acyl Group: The Critical Step in Bombykol Biosynthesis That Is Regulated in Vitro by the Neuropeptide Hormone in the Pheromone Gland of Bombyx mori
- Effect of Dietary Seal and Fish Oils on Lipid Metabolism in Hamsters
- Effect of Dietary Seal and Fish Oils in Triacylglycerol Metabolism in Rats
- Lymphatic Absorption of Seal and Fish Oils and Their Effect on Lipid Metabolism and Eicosanoid Production in Rats
- WS3-1 Application of two-color FISH with liquid-based thin-layer cytological preparations for uterine cancers
- P-22 Detection of chromosomal alterations in ovarian cancers using double-targeted FISH
- Rare-Earth(RE)-Barium Solubility Behaviour in Y(Ba_RE_x)Cu_3O_ and Sm(Ba_RE_x)Cu_3O_ : Electrical Properties of Condensed Matter
- Absence of Solid Solution of the Type, Y(Ba_RE_x)Cu_3O_ and Its Possible Implications : Electrical Properties of Condensed Matter
- Identification of the Receptor-Recognition Site of Bombyxin-II, A Silkmoth Insulin-Like Peptide
- Translational Regulation of the mRNA Encoding the Eukaryotic Translation Initiation Factor 4E in Xenopus
- ^1H Nuclear Magnetic Resonance Study of Hydrogen Distribution in Partially Deuterated Hydrogenated Amorphous Silicon
- Structural Differences between Hydrogenated and Deuterated Amorphous Silicon Films Prepared by Plasma-Enhanced Chemical Vapor Deposition
- ^1H Nuclear Magnetic Resonance Study of Hydrogenated Amorphous Silicon Deposited from a Xe-diluted Silane Plasma
- Prophylactic Effects of Ajoene on Cerebral Injury in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)(Analytical Biochemistry)
- Antidiabetic Effects of Ajoene in Genetically Diabetic KK-A^y Mice
- Antibacterial Effect of Ajoene on Helicobacter pylori in Mongolian gerbils
- Inhibition by Ajoene of Skin-tumor Promotion in Mice(Food & Nutrition Science)
- Inhibition of the Growth of Helicobacter pylori by Oil-Macerated Garlic Extract
- Protective Effect of Ajoene on Acetaminophen-induced Hepatic Injury in Mice(Food & Nutrition Science)
- Significance of MUC1 mucin expression in clear cell adenocarcinoma of the ovary
- Alteration of the Self-incompatibility Phenotype in Brassica by Transformation of the Antisense SLG Gene
- BREAKDOWN OF SELF-INCOMPATIBILITY INBRASSICA BY ANTISENSE RNA OF THE SLG GENE
- Specific expression of hepatocyte nuclear factor-1β in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis
- Effects of Heat and High-Pressure Treatments on Antigenicity of Beef Extract(Food & Nutrition Science)
- Meat Allergy : Investigation of Potential Allergenic Proteins in Beef
- Antimicrobial Activity of the Thiosulfinates Isolated from Oil-Macerated Garlic Extract
- An Organosulfur Compound Isolated from Oil-Macerated Garlic Extract, and Its Antimicrobial Effect
- Antimicrobial Activity of a Compound Isolated from an Oil-Macerated Garlic Extract
- Thermal Gelation Profile Changes in Reconstituted Actomyosin due to Storage under a High Salt Concentration and Low Temperature
- Stabilizing Effect of Tropomyosin on Actin during Storage at Low Temperature
- Antimutagenic Effects of Ajoene, an Organosulfur Compound Derived from Garlic
- Pressure Effects on Circular Dichroism Spectra of Connectin
- Cleavage of Connectin by Calpain and Cathepsin D
- Effects of High Pressure Treatment on Ca^ Release and Ca^ Uptake of Sarcoplasmic Reticulum
- Pressure-induced Ca^ Release from Rabbit Sarcoplasmic Reticulum
- Effect of High Pressure Treatment on the Ultrastructure and Myofibrillar Protein of Beef Skeletal Muscle(Food & Nutrition)
- Visualization of Immobilized Microparticles in Fractured Polymer Gel Surfaces by Atomic Force Microscopy
- Effect of Ion Bombardment on the Properties of Hydrogenated Amorphous Silicon Prepared from Undiluted and Xenon-Diluted Silane
- In Situ Ultraviolet Laser Treatment during Plasma Deposition for the Improvement of Film Qualities in Hydrogenated Amorphous Silicon
- Analysis of the Isoform of Xenopus Euakryotic Translation Initiation Factor 4E
- Morphological Changes in Insect BM-N4 Cells Induced by Nocardamine
- Subcellular Localization of Galactosyltransferase Associated with Tumors in Endometrial and Ovarian Cancer Cells
- Significance of plasminogen activator inhibitor-1 (PAI-1) expression in ovarian clear cell adenocarcinoma(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Application of two-color FISH with liquid-based thin-layer cytologic preparations for uterine adenocarcinomas
- A-7 The expression of β1,4-galactosyltransferase in human trophoblasts
- Structure of Neurosecretory Cells with Immunoreactive Diapause Hormone and Pheromone Biosynthesis Activating Neuropeptide in the Silkworm, Bombyx mori
- The brain neurosecretory cells of the moth Samia cynthia ricini: Immunohistochemical localization and developmental changes of the Samia homologues of the Bombyx prothoracicotropic hormone and bombyxin
- Expression of EAT, an anti-apoptotic gene, in murine embryogenesis and human development
- EAT/mcl-1, a Member of the bcl-2 Related Genes, Confers Resistance to Apoptosis Induced by cis-Diammine Dichloroplatinum (II) via a p53-Independent Pathway
- B-36 Localization of EAT, a Differentiation and Apoptosis-Related Gene, in Adult and Fetal Tissue : A Study using a Newly Established Monoclonal Antibody
- Isolation and Structure of the Sex Pheromone Inhibitor, iAM373, of Enterococcus faecalis
- Quantitative Diagnosis on Magnetic Resonance Images of Chronic Liver Disease Using Neural Networks (Special Section on Nonlinear Theory and Its Applications)
- Neural Network Approach to Characterization of Cirrhotic Parenchymal Echo Patterns (Special Section of Papers Selected from the 7th Digital Signal Processing Symymposium
- Aflastatin A, a Novel Inhibitor of Aflatoxin Production by Aflatoxigenic Fungi
- A monoclonal antibody against a synthetic carboxyl-terminal fragment of the eclosion hormone of the silkworm, Bombyx mori : characterization and application to immunohistochemistry and affinity chromatography : Immunology
- Freezing and Eutectic Points of an Aqueous Amino Acid Solution Containing Ethanol, and the Effect of Ethanol Addition on the Freeze Concentration Process
- Effects of Epigallocatechin 3-O-Gallate on Cellular Antioxidative System in HepG2 Cells
- Studies on the Metal-Protein Complex.XI. : Effect of Ionic Properties of Polypeptides on Metal-catalyzed Fatty Acid Oxidation
- Studies on the Metal-Protein Complex. IX. : Reaction between the Polypeptides and Metals
- Antibacterial Effect of Ajoene on Helicobacter pylori in Mongolian gerbils
- Inhibition of the Growth of Helicobacter pylori by Oil-Macerated Garlic Extract
- Nucleotide Sequence of an Endo-1,4-β-Glucanase Gene (celA) from Clostridium josui
- Cloning of the celB Gene Encoding Endo-1,4-β-Glucanase-2 from Clostridium josui in Escherichia coli and the Properties of the Translated Product
- Purification and Characterization of the Clostridium josui Porphobilinogen Deaminase Encoded by the hemC Gene from a Recombinant Escherichia coil
- Changes in Composition of Non-polar Lipids of the Axis and Root of Germinating Soybeans
- Enhancement of Intestinal IgA Production by Ajoene in Mice
- Synthesis and Anticancer Activities of Lipophyllic Somatostatin Derivatives