Cleavage of Connectin by Calpain and Cathepsin D
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概要
- 論文の詳細を見る
μ-Calpain quickly split the α-connectin in myofibrils into β-connectin, and then produced a 1700-kDa component. Cathepsin D also split α-connectin into β-connectin, further degrading it to fragments smaller than the 1700-kDa component with increasing incubation time. The action of cathepsin D on the connectin molecule was distinctly different from that of μ-calpain in terms of the splitting rate and manner. When freshly excised muscle was exposed to a temperature of 37℃, complete disappearance of connectin (α, βand 1700-kDa component) was observed within 36h. In contrast, at 2℃, about 75% of connectin was retained as β-form even after 3 weeks. The present data suggest that the degradation of connectin in muscle might be caused by μ-calpain in the early stage of aging, and then with time, this action is replaced by m-calpain or cathepsin D. However, the possibility of other intrinsic proteases participating in the degradation of connectin still remains.
- 社団法人日本農芸化学会の論文
- 1995-05-23
著者
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Suzuki Atsushi
Department of Cardiology, Musashino Red Cross Hospital
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IKEUCHI Yoshihide
Department of Animal Science, Faculty of Agriculture, University of Niigata
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Suzuki Atsushi
Biodevelopment Division Central Institute Nagoya Seiraku Co. Ltd.
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Suzuki Atsushi
Department Of Applied Biological Chemistry Faculty Of Agriculture University Of Niigata
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Suzuki Atsushi
Department Of Animal Husbandry Faculty Of Agriculture Tohoku University
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Suzuki Atsushi
Synthetic Crystal Research Laboratory Faculty Of Engineering Nagoya University
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Suzuki Atsushi
Department Of Pathology Obstetrics And Gynecology Keio University School Of Medicine
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Suzuki Atsushi
Basic Research Department Prima Meat Packers Co. Ltd.
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Suzuki Atsushi
Department Of Applied Biochemistry Faculty Of Agriculture University Of Niigata
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Suzuki A
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Suzuki A
Department Of Applied Biological Chemistry Faculty Of Agriculture University Of Niigata
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IKEUCHI Yoshihide
Division of Food Animal Science, Graduate School of Agricultural Sciences, Kyushu University
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KIM Ken
Department of Biosystem Science, Graduate School of Science and Technology, University of Niigata
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Homma Yuji
Department of Applied Biochemistry, Faculty of Agriculture, University of Niigata
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Kim K
Chonnam National Univ. Kwangju Kor
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Homma Yuji
Department Of Applied Biochemistry Faculty Of Agriculture University Of Niigata
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Ikeuchi Y
Division Of Food Animal Science Graduate School Of Agricultural Sciences Kyushu University
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Ikeuchi Yoshihide
Department Of Animal Science Faculty Of Agriculture University Of Niigata
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