Effects of Vitamin B_<12> Analogues With Alternations in the Side Chains of the Corrin Ring on Urinary Methylmalonate Excretion in Vitamin B_<12>-Deficient Rats
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概要
- 論文の詳細を見る
To study how much the side chains of the corrin ring of vitamin B_<12> are involved in the physiological roles of the vitamin, five vitamin B_<12> analogues (cyanocobalamin-b-monocarboxylate, cyanocobalamin-d-monocarboxylate, cyanocobalamin-e-monocarboxylate, cyano-13-epicobalamin, and cyanocobalamin(c-lactam)) with alternations in the side chains were synthesized chemically and then administered orally and intravenously to vitamin B_<12>-deficient rats. Male rats fed a vitamin B_<12>-deficient diet for 11 wk developed a severe vitamin B_<12> deficiency with a high urinary methylmalonate excretion (223.8 ± 136.2 μmol/d) and 〜97% (1.2±0.7ng/g tissue) lower hepatic vitamin B_<12> content. Oral and intravenous administration of cyanocobalamin-b-, -d-, and -e-monocarboxylates and cyano-13-epicobalamin could not improve the severe vitamin B_<12>-deficient status of the rats, indicating that the b-, d-, and e-propionamide side chains of the corrin ring of vitamin B_<12> are important in the absorption, transport, and function of the vitamin in rats. Urinary methylmalonate excretion of the rats that were intravenously administered cyanocobalamin(c-lactam) increased twice as much as those of the other analogue-supplemented rats, suggesting that cyanocobalamin(c-lactam) act as a powerful Cbl-antagonist. The results also indicate that mammalian cells do not contain a system for synthesizing complete vitamin B_<12> from these analogues.
- 社団法人日本農芸化学会の論文
- 1993-04-23
著者
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NAKANO Yoshihisa
Graduate School of Life and Environmental Sciences of Osaka Prefecture University
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TAMURA Yoshiyuki
Laboratory of Nutrition and Food Science, Hagoromo-gakuen College
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Yoshiyuki Tamura
Laboratory Of Nutrition And Food Science Hagoromo University Of International Studies
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Saido Hisako
Department Of Applied Biological Chemistry University Of Osaka Prefecture
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Nakano Yoshihisa
Department Of Agricultural Chemistry
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Watanabe Fumio
Laboratory of Nutrition and Food Science, Hagoromo-gakuen College
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Manai Yasuo
Department of Agricultural Chemistry, University of Osaka Prefecture
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Manai Yasuo
Department Of Agricultural Chemistry University Of Osaka Prefecture
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