No Detectable Transfer of Dietary Lactoferrin or Its Functional Fragments to Portal Blood in Healthy Adult Rats
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概要
- 論文の詳細を見る
We investigated the transfer of dietary bovine lactoferrin (LF) and its functional lactoferricin (LFcin) B-containing fragments to the portal blood of healthy adult rats by using several techniques. After a single administration of 125I-labeled LF, radioactive bands were detected in autoradioluminograms of the portal blood, but similar bands were also observed after the administration of [125I]NaI. Although ovalbumin was detected by ELISA at 3–18 ng/ml in the portal blood plasma after an overnight administration, no LF was detected (≤1.5 ng/ml). The antibody-captured ovalbumin fragments, but not the LF fragments, were detected in the plasma by surface-enhanced laser desorption/ionization affinity mass spectrometry (SELDI affinity MS). We finally attempted to detect the LFcin B-containing fragments by SELDI affinity MS with on-chip LFcin B-conversion, but could not detect them (≤1 ng/ml) in the portal blood after the LF ingestion. The level of LF or its functional fragments transferred to the portal blood was therefore extremely low, if any.
- 社団法人 日本農芸化学会の論文
- 2004-04-23
著者
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Teraguchi S
Morinaga Milk Ind. Co. Ltd. Kanagawa Jpn
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Teraguchi Susumu
三重大学保健管理センター
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Yamauchi Koji
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Teraguchi Susumu
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd
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TAMURA Yoshitaka
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
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Tamura Yoshiyuki
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Yoshiyuki Tamura
Laboratory Of Nutrition And Food Science Hagoromo University Of International Studies
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Tamura Yoshiyuki
Second Depertment Of Internal Medicine School Of Medicine The University Of Tokushima
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Wakabayashi Hiroyuki
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Tanioka Yuri
Department Of Nutrition Junior College Of Tokyo University Of Agriculture
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Tokunaga Yoko
Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agric
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Yamauchi Koji
Toxicologic Pathology Drug Safety Research Laboratories Astellas Pharma Inc.
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KUWATA Hidefumi
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
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Tamura Yoshitaka
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Yamauchi Koji
Nutritional Science Institute Morinaga Milk Industry Co. Ltd.
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Wakabayashi H
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Kuwata Hidefumi
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Teraguchi Susumu
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Teraguchi Susumu
Nutritional Science Laboratory
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