Increased Staphylococcus-killing Activity of an Antimicrobial Peptide, Lactoferricin B, with Minocycline and Monoacylglycerol(Microbiology & Fermentation Technology)
スポンサーリンク
概要
- 論文の詳細を見る
This study aimed to find antibiotics or other compounds that could increase the antimicrobial activity of an antimicrobial peptide, lactoferricin B (LFcin B), against Staphylococcus aureus, including antibiotic-resistant strains. Among conventional antibiotics, minocycline increased the bactericidal activity of LFcin B against S. aureus, but methicillin, ceftizoxime, and sulfamethoxazole-trimethoprim did not have such an effect. The combination of minocycline and LFcin B had synergistic effects against three antibiotic-resistant strains of S. aureus, according to result of checkerboard analysis. Screening of 33 compounds, including acids and salts, alcohols, amino acids, proteins and peptides, sugar, and lipids, showed that medium-chain monoacyl-glycerols increased the bactericidal activity of LFcin B against three S. aureus strains. The short-term killing test in water and the killing curve test in growing cultures showed that a combination of LFcin B and monolaurin (a monoacylglycerol with a 12-carbon acyl chain) killed S. aureus more rapidly than either agent alone. These findings may be helpful in the application of antimicrobial peptides in medical or other situations.
- 社団法人日本農芸化学会の論文
- 2002-10-23
著者
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Teraguchi S
Morinaga Milk Ind. Co. Ltd. Kanagawa Jpn
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Teraguchi Susumu
三重大学保健管理センター
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Teraguchi Susumu
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd
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TAMURA Yoshitaka
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
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Tamura Yoshiyuki
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Yoshiyuki Tamura
Laboratory Of Nutrition And Food Science Hagoromo University Of International Studies
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Tamura Yoshiyuki
Second Depertment Of Internal Medicine School Of Medicine The University Of Tokushima
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Wakabayashi Hiroyuki
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Tanioka Yuri
Department Of Nutrition Junior College Of Tokyo University Of Agriculture
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Tokunaga Yoko
Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agric
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Tamura Yoshitaka
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Wakabayashi H
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Teraguchi Susumu
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
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Teraguchi Susumu
Nutritional Science Laboratory
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