Protective Effect of Lactoferricin against Toxoplasma gondii Infection in Mice.
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概要
- 論文の詳細を見る
The protective effect of lactoferricin against Toxoplasma gondii infection was examined in experimental murine toxoplasmosis. All mice orally administered 5.0 mg of lactoferricin, and challenged with cysts of T. gondii at a dose of LD90 survived until the end of experiment (35 days post challenge). Intraperitoneal administration of 0.1 mg of lactoferricin also prevented death in 100% of treated mice challenged with T. gondii cysts. In contrast, 80% of untreated mice died of acute toxoplasmosis within 14 days post challenge. In the mice treated perorally with lactoferricin, the number of cysts in the brain was significantly lower than that in untreated mice. Levels of interferon-r in the serum of infected mice treated perorally with lactoferricin showed a tendency to lower than those in the infected mice without treatment. These results demonstrate that oral administration of lactoferricin induces resistance to T. gondii infection in mice.
- 公益社団法人 日本獣医学会の論文
著者
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Yamauchi Koji
Nutritional Science Institute Morinaga Milk Industry Co. Ltd.
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Tanaka Tetsuya
Department Of Biological Function Graduate School Of Science Osaka City University
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Saito Atsushi
Department Of Biochemistry Graduate School Of Biomedical Sciences Hiroshima University
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SHIMAZAKI Kei-ichi
Dairy Chemistry Laboratory, Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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YAMAUCHI Koji
Nutritional Science Laboratory, Morinaga Milk Industry, Co., Ltd.,
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OMATA Yoshitaka
Department of Basic Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
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TANAKA Tetsuya
Department of Veterinary Physiology, Obihiro University of Agriculture and Veterinary Medicine
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SHIMAZAKI Kei-ichi
Dairy Science Laboratory, Animal Science Department, Faculty of Agriculture, Hokkido University
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ISAMIDA Tsuya
Department of Veterinary Physiology, Obihiro University of Agriculture and Veterinary Medicine
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