Difference in Self-Assembling Morphology of Peptide Nanorings

概要

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We synthesized the peptide nanorings of cyclo[-(d-Ala-l-Gln)3], cyclo[-(d-Cys-l-Gln)3], cyclo[-d-Cys-l-His-d-Ala-l-Asn-Gly-l-Gln-] and cyclo[-(l-Gln)5], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(d-Ala-l-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(d-Cys-l-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-d-Cys-l-His-d-Ala-l-Asn-Gly-l-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the d,l-peptide nanotubes have very straight forms, the homo-l-peptide of cyclo[-(l-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.
Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
2005-11-15