<原著>鶏冠由来低分子ヒアルロン酸の化学組成とヒト肌への臨床試験による保湿効果

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[Synopsis] The chemical compositions of low-molecular weight （low-MW） hyaluronic acid （HA） from comb and the effect of keepingb moisture contents on skin by a clinical test were investigated. The low-MW-HA prepared from comb contained the following components: moisture 2.2 ～ 2.6％, nitrogen 3.84％, total protein 3.04％, free amino acid 4.08％, N-acetyl-D-glucosamine 0％, HA 13.4％ and dextrin（ food additives） 75.0％. The main components of the low-MW-HA were two components, MW 1,500（ 47％） and MW. 5,000（ 33％）. We studied the effect of low-MW-HA（ Will-HA） on the effect of keeping moisture contents of skin by a clinical test. The clinical test was done in a national hospital in the Peoples Republic of China in 2006. As a result, it was shown that the low-MW-HA have the effect of keeping moisture in the skin.