清酒酵母の代謝に関する研究 : (第7報) α-フェネチルアルコールによる呼吸阻害作用に対するL-アスパラギン酸の共同効果とL-α-アラニンの保護効果

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In a previous paper, the authors reported that the inhibition biosynthesis of respiratory enzymes caused by α-phenethyl alcohol (α-PEA) was prevented by a simulataneous addition of a large amount of L-α-alanine to a growth medium containing α-PEA. This suggests that the respiratory inhibition by α-PEA has some relationship to amino acids and nitrogen sources in the growth medium. So in this paper, it is attempted to elucidate the relationship between α-PEA and amino acid.Among various nitrogen sources used for the cell growth, the respiratory inhibition by α-PEA was observed only with casamino acids. Of the components of casamino acids, L-aspartic acid was most effective for the decrease of Qo_2 by α-PEA. Furthermore, guanine and cytosine, which are metabolites derived from L-aspartic acid, also promoted the inhibitory effect of α-PEA like L-aspartic acid. These facts fuggest that this action of α-PEA might be related to the biogenesis of nucleic acids, but no difference in nucleic acid content was detected between the cells grown with or without α-PEA. On the other hand, L-α-Alanine, which possesses a protecting effect against the action of α-PEA, markedly inhibited the incorporporation of L-aspartic acid into cells. And Qo_2 values of cells were restored with the decrease of the incorporation of L-aspartic acid. Having no protecting effect against the action of α-PEA, Other amino acids, such as L-valine and glycine, did not show such an interesting effect against the incorporation of L-aspartic acid. From these facts, it would be considered that α-PEA inhibits the biosynthesis of respiratory enzymes whin it is coexistent with L-aspartic acid or its metabolites although the mechanism of it remained to be elucidated, and that L-α-alanine interferes with the action of α-PEA by inhibiting the incorporation of L-aspartic acid into cells.
社団法人日本生物工学会の論文
1971-05-25

清酒酵母の代謝に関する研究 : (第7報) α-フェネチルアルコールによる呼吸阻害作用に対するL-アスパラギン酸の共同効果とL-α-アラニンの保護効果

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