Ethanol Production from a Mixture of Glucose and Xylose by a Novel Co-Culture System with Two Fermentors and Two Microfiltration Modules

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We developed a novel co-culture system composed of two fermentors and two microfiltration modules for efficient ethanol production from a mixture of glucose and xylose by co-culture of Pichia stipitis and Saccharomyces cerevisiae. In a conventional co-culture where P. stipitis and S. cerevisiae wre inoculated simultaneously into a single fermentor, it was impossible to maintain the specific oxygen uptake rate (qO_2) at an optimum value for ethanol production from xylose by P. stipitis due to oxygen consumption by S. cerevisiae. The ethanol concentration obtained in the conventional co-culture was lower than that in a single culture of P. stipitis alone in which qO_2 was adjusted to an optimum level depending upon the kind of sugar consumed. The proposed co-culture system allowed regulation of the dissolved oxygen cncentration at a level suitable for an individual yeast in each fermentor as well as the successufl exchange of culture medium between two fermentors. When P. stipitis and S. cerevisiae were cultivated individually under different oxygen supply conditions in the new co-culture system, the yield ad productivity of ethanol from a glucose and xylose mixture were higher than in single culture of P. stipitis alone.
社団法人日本生物工学会の論文
1997-07-25