動物用医薬品の残留規制とLC/MSによる分析

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In recent years, there has been a steadily growing demand in Japan for variety of livestock products as the eating habits of the Japanese become more Westernized. This has brought about great changes in the methods of raising livestock in Japan and elsewhere, notably with larger numbers of animals being raised together within limited space. In spite of the increased demand for meat and fowl, the Japanese, who populate an island archipelago, still prize seafood as a main source protein. The internationally implemented limitations on fishing, necessary for conservation, have created a need for farm-raised seafood to supplement catches. This relatively new industry is becoming more prosperous year by year. Various veterinary drugs, such as antibiotics and synthetic antibacterials, are widely used in the rearing of food-producing animals to prevent and treat infectious diseases and to promote their growth. Although these drugs have been a boon to the aquiculture industry, there are some problems in using them in the same way that the use of certain pesticides in agriculture has been paradoxically both benefical and detrimental to human and animal welfare. Residues of antibiotics and synthetic antibacterials are found in the edible tissues and resistant bacterial strain have appeared. According to the Japanese Food Sanitation Law, no food should contain antibiotics and, in addition, meat, poultry eggs, fish, and shellfish should not contain synthetic antibacterials. In order to monitor the drug residues levels in livestock products, simple and reliable method are required. For the analysis of residual veterinary drugs in food, many assay techniques have been developed such as HPLC and LC/MS. Legal regulation and LC/MS analysis of these chemicals are outlined in this paper.
日本質量分析学会の論文
2006-06-01

動物用医薬品の残留規制とLC/MSによる分析

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