Tetrapetalone A, a Novel Lipoxygense Inhibitor from Streptomyces sp.
スポンサーリンク
概要
- 論文の詳細を見る
A simple new assay was designed for lipoxygenase inhibitors. This assay was used to find the novel lipoxygenase inhibitor, tetrapetalone A (1). Tetrapetalone A (1), C26H33NO7, was isolated from Streptomyces sp. USF-4727 strain. Its planar structure was determined by spectroscopic evidence and by methylating with diazomethane to show the presence of a novel tetracyclic skeleton and a β-D-rhodinosyl moiety. The stereochemistry of 1 was investigated by the coupling constant in the 1H-NMR spectrum, NOE correlations, modified Mosher’s method and derivation. We have reported the structural elucidation of 1 in our previous paper. However, further investigation gave another structure for 1, which is described in this paper. Tetrapetalone A showed similar inhibitory activity against soybean lipoxygenase to the two well-known lipoxygenase inhibitors, kojic acid and NDGA, while methylated tetrapetalone A (2) showed little inhibitory activity, even at a concentration of 1 mM.
- 社団法人 日本農芸化学会の論文
- 2004-01-23
著者
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KOMODA Toshikazu
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
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ABE Naoki
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
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SUGIYAMA Yasumasa
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
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HIROTA Akira
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
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KOSHINO Hiroyuki
Molecular Characterization Team, RIKEN
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Abe N
Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Abe Naoki
School Of Food And Nutritional Sciences University Of Shizuoka:(present Address)department Of Nutrit
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Hirota Akira
School Of Food And Nutritional Sciences Univ. Of Shizuoka
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Hirota A
Department Of Agricultural Chemistry University Of Osaka Prefecture
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Hirota Akira
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Hirota Akira
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
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Hirota H
Protein Research Group Riken Genomics Sciences Center
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Hirota Hiroshi
Protein Research Group Riken Genomic Sciences Center And Division Of Supramolecular Biology Yokohama
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YOSHIDA Kayo
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
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IMACHI Misako
Bruker BioSpin K. K.
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Koshino Hiroyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University:(present Address) Ri
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Koshino H
Molecular Characterization Team Advanced D&s Center Riken
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Koshino Hiroyuki
Molecular Characterization Characterization Center Riken(the Institute Of Physical And Chemical Rese
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Komoda Toshikazu
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
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Yoshida Kayo
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
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Sugiyama Yasumasa
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
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Abe N
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
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Abe Naoki
School Of Food And Nutritional Sciences University Of Shizuoka
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Hirota Hiroshi
Protein Research Group Riken Genomic Science Center
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Abe Naoki
Laboratory Of Applied Microbiology Department Of Microbial Biotechnology Graduate School Of Agricult
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