Novel DPPH Radical Scavengers, Demethylbisorbibutenolide and Trichopyrone, from a Fungus
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概要
- 論文の詳細を見る
In our screening program for antioxidants with 1,1-diphenyl-2-picrylhydrazyl (DPPH)-radical scavenging activity, two novel compounds, demethylbisorbibutenolide (1) and trichopyrone (2), were isolated from the fermentation broth of the fungus of USF-4860 strain isolated from a soil sample. The structures of these compounds were determined from spectroscopic evidence. The biosynthetic origin of the carbon atoms of 2 was unambiguously determined by feeding experiments using 13C-labeled precursors and elucidation of the 13C-NMR spectrum of 13C-labeled 2. These studies showed that 2 was derived from five acetates and a methyl group of methionine. In the DPPH-radical scavenging assay, 1 and 2 gave ED50 values of 149 and 167 μM after standing for 2.0 hr. Compound 2 reacted with the DPPH radical to form reaction product 3 which was determined to be 1-[4-(3,4-dihydro-3-methyl-6-{1,3-pentadienyl}-2,4-dioxo-2H-pyran-3-yl)-phenyl]-1-phenyl-2-picrylhydrazine from spectroscopic evidence.
- 社団法人 日本農芸化学会の論文
著者
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Abe Naoki
School Of Food And Nutritional Sciences University Of Shizuoka:(present Address)department Of Nutrit
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Hirota Akira
School Of Food And Nutritional Sciences Univ. Of Shizuoka
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SUGIYAMA Yasumasa
School of Food and Nutritional Sciences, University of Shizuoka
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WASHIDA Kazuto
School of Food and Nutritional Sciences, University of Shizuoka
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