Novel DPPH Radical Scavengers, Bisorbicillinol and Demethyltrichodimerol, from a Fungus

元データ 1998-04-23 社団法人日本農芸化学会

概要

In our screening program for antioxidants with DPPH radical scavenging activity, we isolated four yellowish compounds from the fermentation broth of Trichoderma sp. USF-2690 strain isolated from a soil sample : two were novel compounds designated bisorbicillinol (1) and demethyltrichodimerol (2), and two were known compounds bisvertinolone (3) and trichodimerol (4). The structures of 1 and 2 were elucidated by spectroscopic evidence and chemical modification. Two compounds seemed to be the oxidized dimers of sorbicillin. In the evaluation of DPPH radical scavenging activity, bisorbicillinol gave the lowest ED_<50> value (31.4μM) among the four compounds, equal to that of BHT (27.0μM).

著者

ABE Naoki Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
HIROTA Akira Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
Abe N Faculty Of Applied Bio-science Tokyo University Of Agriculture
Abe Naoki School Of Food And Nutritional Sciences University Of Shizuoka:(present Address)department Of Nutrit
Hirota Akira School Of Food And Nutritional Sciences Univ. Of Shizuoka
Hirota A Department Of Agricultural Chemistry University Of Osaka Prefecture
Hirota Akira Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
Hirota Akira Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
Murata Takeomi Department Of Biological Chemistry Faculty Of Agriculture Shizuoka University
Murata T Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
MURATA Takashi Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka
Abe N Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
Abe Naoki School Of Food And Nutritional Sciences University Of Shizuoka
Abe Naoki Laboratory Of Applied Microbiology Department Of Microbial Biotechnology Graduate School Of Agricult

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