Two Oxazolyl Compounds and a Monosubstituted α-Pyrone as Free-radical Scavengers Isolated from a Fungus
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概要
- 論文の詳細を見る
In the course of our screening for free radical scavengers, (1'E)-erythro-4-(3', 4'-dihydroxypentenyl)oxazole (1) (1'E, 4'S)-4-(3'-oxo-4'-hydroxypentenyl)oxazole (2) and 6-pentyl-α-pyrone (3) were isolated from an unidentified fungal metabolite. These compounds, especially novel oxazolyl compound 2, inhibited the bactericidal effect of the Fenton reagent toward Bacillus subtilis. They and their acetylated compounds (diAc-1 and Ac-2) also showed inhibitory activity against linoleate autoxidation. Furthermore, 1-3 inhibited oxidative enzymes (soybean lipoxygenase and mushroom tyrosinase). To investigate the radical scavenging mechanism of 3, two oxidized products (4 and 5) were isolated from the reaction mixture of 3 and the Fenton reagent. Compounds 4 and 5 seemed to be derived from 3 by scavenging the hydroxyl radical.
- 社団法人日本農芸化学会の論文
- 1997-09-23
著者
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Hirota Akira
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
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Morimitsu Yasujiro
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka:(p
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Morimitsu Yasujiro
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka
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Morimitsu Yasujiro
Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka:la
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