Role of laparoscopic vascular changes in fatty liver. Comparative study with intrahepatic microvasculature using experimental model. : Comparative study with intrahepatic microvasculature using experimental model

概要

論文の詳細を見る
Laparoscopic vascular pattern in the course of fatty liver was investigated comparing with intrahepatic microvasculature of fatty liver induced by choline deficient diet (CDD) in the rat. Early laparoscopic change seen was an increase in number of portal branches. Microangiograms of early experimental lesion represented amorphously increased portal branches in the peripheral area, indicating principal vascular changes in fatty liver are deranged portal system. Dilatation, irregularity and tortuosity in the portal system became conspicuous with progression of the disease. Laparoscopic evidence for arterioles were reflected not only by intrahepatic inflammation, but by parallel development of regenerative nodules. Arteriolar vascularization seen in the stroma was characteristic in early cirrhotic stage, whereas it was pronounced on the surface in enlarged nodules. Experimental model showed that the larger the nodules, the more hypovascular in the nodules. It is concluded that capsular vasculature in fatty liver is closely related to the intrahepatic vascular disorder, and microcirculatory derangement is highly involved in the progression of the disease.