肝細胞癌およびその類縁病変の画像解析による細胞計測学的研究-とくに核, 細胞形質の pleomorphism について

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Micro-morphometric analyses of 200 various liver disease cases were performed with the aid of on image analyzer (Zeiss IBAS-1). Attention was concentrated on two nuclear and cytoplasmic parameters: a form (shape) factor for individual cells and a coefficient of variance. The results obtained were as follows: 1) Whereas the form factor for nuclei in normal livers and non-tumorous liver disease cases was larger than 0.94, a marked decrease became apparent in accordance with the grade of HCC dedifferentiation. 2) The coefficient of variance of nuclei was significantly increased in accordance with the grade of HCC dedifferentiation. 3) The form factor for cytoplasm in tumor cells showed remarkably greater irregularity than normal liver and non-tumorous liver disease values.
社団法人日本肝臓学会の論文