A study on high copper deposition in rodent liver induced by low-protein diet. An experimental copper administration toSD rats from embryonal to neonatal periods.:An experimental copper administration to SD rats from embryonal to neonatal periods

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The sporadic occurrence of childhood liver cirrhosis has been assumed to have an etiology of excess copper intake. We attempted to clarify the relation between malnutrition and abnormal copper deposition in the liver, using the following experimental design: Sprague-Dawley rats were divided into two groups, an usual diet group and a low-protein diet group. Excess copper was administered to rats in the drinking water from embryo to 8 weeks after birth. Rats were sacrificed at the 7th, 28th and 56th day after birth, and various laboratory tests were examined. The results obtained were: No copper deposition in the liver was demonstrated in the normal-diet group. However, marked copper deposition in centrilobular hepatocytes was revealed in the low-protein diet group, 8th experimental week. Although, copper deposition had been reported to be periportal in cases of copper deposited type childhood cirrhosis, Wilson's disease and PBC, the deposition was centrilobular in the present study. The possible etiology of the present experiment was discussed.
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