著明な低蛋白血症と脾臓の多発性結節性病変を伴った組織球症の1剖検例

概要

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A 58-year-old woman was admitted to Kitasato University Hospital with edema in the lower extremities complicated by pancytopenia, hypoproteinemia, and marked splenomegaly. In blood samples no anomalous cells were detected in the peripheral blood nor in the bone marrow. On the 108th day in hospital the patient died of Pneumocystis carinii pneumonia. Autopsy disclosed several nodular lesions in the parenchyma of the spleen. The lesions, up to 2.5×2.0 cm in diameter, were composed of atypical histiocytes characterized by extensive erythrophagocytic activity and considerable extramedullary hematopoiesis. An abundance of erythrophagocytic histiocytes also appeared in the liver, lymph nodes, and bone marrow. Protozoiasis associated with Pneumocystis carinii pneumonia was found bilaterally in the lungs. No notable abnormalities were observed in the mucosa of the gastrointestinal tract. Broadly categorized as histiocytosis, the present case suggested that hypoproteinemia may be a reliable indicator of abnormally proliferating histiocytes.
北里大学の論文
1990-12-31