Mode of Action for Mitomycin C Inactivating Factors of Pseudomonas convexa 4-87(Biological Chemistry)
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概要
- 論文の詳細を見る
Mutagenicity of the anti-cancer agent mitomycin C was suppressed by incubation with the desmutagenic factor of Pseudomonas convexa 4-87 and NAD(P)H. The main reaction products were isolated and identified as 1,2-cis- and 1,2-trans-2,7-diamino-1-hydroxymitosene and 2,7-diaminomitosene. A reaction scheme through reduction of the benzoquinone moiety, elimination of the methoxy group, opening of the aziridine ring, and formation of mitosene-type derivatives was proposed. The desmutagenic factor of P. convexa 4-87 was shown to be a quinone-reducing enzyme requiring NAD(P)H, but its physiological role in the cell remains unclear.
- 社団法人日本農芸化学会の論文
- 1988-12-23
著者
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KODAMA Tohru
Department of Textile Science and Technology, Shinshu University
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MINODA Yasuji
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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Minoda Y
Univ. Tokyo Tokyo Jpn
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Minoda Yasuji
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Kodama T
Univ. Tokyo Tokyo Jpn
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Kodama Tohru
Department Of Agricultural Chemistry The University Of Tokyo
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YAMAGATA Hisashi
Department of Agricultural Chemistry, The University of Tokyo
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Yamagata Hisashi
Department Of Agricultural Chemistry The University Of Tokyo
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Kodama Tohru
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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