LDH H型サブユニット変異を示した二家系

概要

論文の詳細を見る
It is well known that LDH is a tetramer of H and M subunits. In rare cases however, another subunit (variant) is recognized (H' or M'). There were no reports of these variants in Japan until 1974. This paper reports two families in which subunit variants were reported. Case 1 : 31 year old female. The patient reported to our hospital with the chief complaint of infertility and liver function tests showed high LDH activity. The LDH isozyme pattern showed changes characterized by broadness of pattern in LDH_1, LDH_2 and LDH_3 and deviation to the cathode. LDH_1 was separated by polyacrylamide gel electrophoresis into many sub-bands derived from a combination of two forms of LDH subunit. Examination of the patient's family revealed an uncle with the same subunit variant. Case 2 : 28 year old male. The patient was admitted for duodenal ulcer and the LDH H type subunit was detected in the patient and his mother. The electrophoretic results were the same as case number 1.
北里大学の論文
1978-12-31