Studies on 1,3-Dithiolium Cations. II. Reactions of 4-Phenyl Derivatives with Nucleophilic Reagents
スポンサーリンク
概要
- 論文の詳細を見る
Nucleophilic reagents attacked exclusively to C-2 position of 4-phenyl-1,3-dithiolium cation derivatives and the corresponding 1,3-dithioles were obtained in good yields. Thus, 2-amino-, 2-aminothiocarbonylthio-, 2-phenylthio-1,3-dithioles were yielded. LiAIH_4 reduction furnished 1,3-dithiole and hydride abstraction gave original cation. 1,3-Dithiolium cation acted as a Bronsted acid and conjugate base carbinol was isolated. Similarly, covalent 2-alkoxy compounds were easily obtained and regenerated cation by the action of acid. Grignard reaction toward cation opened the new routes to 2-substituted 1,3-dithiolium cations.
- 公益社団法人日本薬学会の論文
- 1969-09-25
著者
-
平井 健太郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
-
高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
関連論文
- Studies on Pyrimidine Derivatives and Related Compounds. LXXV. Reactions of Thiazolium Salts with Diethyl Acylphosphonates and Hydroxylation of Some 3-Oxo-2,3-dihydro-4H-1,4-thiazine Derivatives
- Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6
- Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).
- Studies on the Pyrimidine Derivatives and Related Compounds. XL. Reaction of 3-Benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium Salts with Diethyl Benzoylphosphonate
- Studies on the Pyrimidine Derivatives and Related Compounds. XXXIX. On the Oxidation Products of 2-Pheny1-4-(2-methyl-4-amino-5-pyrimidyl)methyl-5-methyl-6-(2-benzoyloxy or hydroxy)-ethyl-4H-1,4-thiazin-3(2H)-one
- 14.ビタミンB_1関連チアゾール誘導体とDiethylbenzoylphosphonateとの反応(第155回会議研究発表要旨)
- Studies on the Pyrimidine Derivatives. XXVII. A New Method for Synthesis of Diethyl Ethoxycarbonylphosphite from Tris (ethoxythiocarbonyl) Phosphorotrithioite, and on the Reactions of these Organo-phosphorus Compounds with Thiamine Sodium Salt.
- Studies on Pyrimidine Derivatives and Related Compounds. LIII. The Reaction of Thiamine with Diethyl Acetylphosphonate (Supplement) and the Synthesis of Pseudothiamine
- Studies on Pyrimidine Derivatives and Related Compounds. LII. Reaction of Thiamine with Phosphites. (1)
- 12.S-Thionocarbonylthiamine類の経口投与時の血中ビタミンB_1濃度と抗炎症作用(第182回会議研究発表要旨)
- Studies on the Pyrimidine Derivatives and Related Compounds. XXXV. On the Reaction Product of Thiamine with Diethyl Benzoylphosphonate
- Peptido-aminobenzophenones-Novel Open-ring Derivatives of 1,4-Benzodiazepines
- Interaction of Peptido-aminobenzophenones with Benzodiazepine Receptors
- Studies on Pyrimidine Derivatives and Related Compounds. XCIV. On the Oxidation Products of 2-Substituted-2,3-dihydro-4H-1,4-thiazin-3-one Derivatives. (2)
- On the Reaction of Dialkyl Acylphosphonate with 2-Methyl-1,3,4-thiadiazolium Salts
- On the Reaction of Dialkyl Acylphosphonate with 2-Methylthiazolium Salts
- On the Reactions of 1,3,4-Oxadiazolium Salts with Dialkyl Acylphosphonates. A Novel Synthesis of 1,3,4-Oxadiazin-5-one Derivatives
- Pyrimidine誘導体及び関連化合物の研究(第89報) : ビタミンB_1とジエチルアシルホスホネートとの反応
- Studies on Pyrimidine Derivatives and Related Compounds. LXXXVII. Reaction of Thiamine Analogues with Diethyl Benzoylphosphonate
- On the Reactions of Oxazolium Salts with Dialkyl Acylphosphonates. A Novel Synthesis of 1,4-Oxazin-3-one and Azetidin-2-one Derivatives
- Studies on Pyrimidine Derivatives and Related Compounds. LXXVII. Reaction of Thiamine Analogues with Diethyl Benzoylphosphonate
- Thiamine Thiazole-C_2位の反応性について
- 3.ThimineのThiazolium-C_2位の反応性に関する化学的研究(日本ビタミン学会 : 第24回大会研究発表要旨)
- Pyrimidine誘導体および関連化合物の研究(第74報) : Thiamine関連化合物とDialkyl Benzoylphosphonatesの反応(有機化学)
- Studies on Pyrimidine Derivatives and Related Compounds. LXXIII. Syntheses and Reactions of Thiamine Sulfur Analogues and Related Derivatives. (2)
- Studies on Pyrimidine Derivatives and Related Compounds. LXXII. Syntheses and Reactions of Thiamine Sulfur Analogues and Related Derivatives. (1)
- Studies on Pyrimidine Derivatives and Related Compounds. LXXI. Reaction of Thiamine Anhydride with Thiols
- 8.Thiamineおよび関連化合物の分解挙動(ビタミンB研究委員会第203回会議研究発表要旨)
- Studies on Pyrimidine Derivatives and Related Compounds. LXX. A Novel Reaction of Thiamine Anhydride
- Studies on Pyrimidine Derivatives and Related Compounds. LXIX. Sythesis of Thiamine Free Base
- Studies on Pyrimidine Derivatives and Related Compounds. LXVIII. Reactions of Dialkyl Acylphosphonates with 1,3-Disubstituted Benzimidazolium Halides
- Studies on Pyrimidine Derivatives and Related Compounds. LXVII. Reaction of Thiadiazolium Derivatives with Dialkyl Acylphosphonates
- Studies on Pyrimidine Derivatives and Related Compounds. LXVI. Reactions of Dialkyl Acylphosphonates with 1,3,4-Thiadiazolium Derivatives
- Investigation on the Reaction of Benzazolium Salts with Base
- Studies on Pyrimidine Derivatives and Related Compounds. LIX. Syntheses of 2,3-Dihydro-1H-pyrazolo [5,1-b] purin-2-ones
- Synthesis and Reactions of Thiaminedisulfide Sulfur Derivatives
- Reactions of 2-Dialkylamino-5-phenyl-1,3-oxathiolium Cation with Nucleophiles Containing an Amino Group
- Syntheses of 2-Disubstituted-amino-4-arylthiazol-5-ylalkanoic Acids
- Studies on the Urinary Metabolites of Isophosphamide and Its Activated Species in Rabbits
- Synthesis, Stereochemistry and Antitumor Activity of 4-Hydroperoxyiso-phosphamide (NSC-227114) and Related Compounds
- Syntheses of New Cyclophosphamide Derivatives Having 1,3,4,2-Oxadiazaphosphorinane and Related heterocyclic Systems
- Addition Reaction of 3-Substituted-4-methyl-5- (2-hydroxy) ethyl-thiazolium Salt with Diaryl Carbodiimide
- Studies on Pyrimidine Derivatives and Related Compounds. LXXXI. Reactions of Aryl Isothiocyanates with Thiamine and Related Thiazolium Ylides
- Studies on Pyrimidine Derivatives and Related Compounds. LXII. Cycloadditions of Alkyl Isothiocyanates with Thiamine and Related Thiazolium Ylids and Facile Conversions of the Adducts to Dihydroimidazo [4,5-d] thiazole Derivatives
- Studies on Pyrimidine Derivatives and Related Compounds. LX. Synthesis of Hydroxymethylthiamine
- Studies on Pyrimidine Derivatives and Related Compounds. LIV. Reactions of Thiamine with α-Ketoaldehydes
- ビタミンB研究委員会第230回会議研究発表要旨
- 7.O-Tetrahydropyranyl-S-alkoxycar-bonylthiamineの製法について(第143回会議研究発表要旨)
- 13.アクリロニトリルより2-Methyl-4-amino-5-acetaminomethylpyrimidineを合成する場合の中間体について(第84回協議会研究発表要旨)
- Studies on Pyrimidine Derivatives and Related Compounds. XLIX. Several Reactions of 1-[(2-Methyl-4-amino-5-pyrimidinyl) methyl]-3-alkyl-4-(2-hydroxyethyl)-5-methyl-imidazolium Salts.
- Studies on Pyrimidine Derivatives and Related Compounds. XLIV. Syntheses of Thiazolo [3,2-a] pyrimidine Derivatives
- Studies on Pyrimidine Derivatives and Their Related Compounds. XCI. On the Oxidation Products of 2-Substituted-1,4-thiazin-3-one Derivatives
- Studies on Pyrimidine Derivatives and Their Related Compounds. LXXXVI. Unusual Reactions of Thiamine Derivatives
- Synthese of 4-Aryliminoparabanic Acids and 2-Arylimino-2,3-dihydro-1,4-thiazine Derivatives via 2-N, N'-Diarylamidinothiazolium Salts
- Studies on Pyrimidine Derivatives and Related Compounds. LXXX. Unusual Reactions of Thiamine Free Base with Electrophilic Reagents. (2)
- Studies on Pyrimidine Derivatives and Their Related Compounds. LXXVIII. Unusual Reactions of Thiamine Free Base with Some Electrophilic Reagents
- Studies on Pyrimidine Derivatives and Related Compounds. XLV. On Some Synthetic Methods of N-[1-(2-Oxo-1,3-oxathian-4-ylidene) ethyl]-N-[(2-methyl-4-amino-5-pyrimidinyl)-methyl] formamide
- Studies on 1,3-Dithiolium Cations. III. Stability and Electronic Structure of 4-p-Substituted Phenyl Derivatives
- Studies on Pyrimidine Derivatives and Related Compounds. LXV. On the Reactions of Thiamine with Carbon Disulfide
- 2.Mercaptoethylthiamineの2、3の反応(ビタミンB研究委員会 第192回会議研究発表要旨)
- Studies on 1,3-Dithiolium Cations. II. Reactions of 4-Phenyl Derivatives with Nucleophilic Reagents
- Studies on 1,3-Dithiolium Cations. I. A Novel Synthetic Method of 4-p-Substituted Phenyl Derivatives and Related Compounds
- 4.ピリミジン誘導体および関連化合物の研究(LXXXVI)Thiamine anhydrideの反応(3)p-ニトロチオフェノールおよびチオール酢酸との反応(日本ビタミン学会 第21回大会研究発表要旨)
- 3.ピリミジン誘導体および関連化合物の研究(LXXXV)Thiamine anhydrideの反応(2)チオフェノールおよびp-チオクレゾールとの反応(日本ビタミン学会 第21回大会研究発表要旨)
- 2.ピリミジン誘導体および関連化合物の研究(LXXXIV)Thiamine anhydrideの反応(1)COSおよびH_2Sとの反応(日本ビタミン学会 第21回大会研究発表要旨)
- 1.Thiamine anhydrideの1新反応(ビタミンB研究委員会 : 第190回会議研究発表要旨)
- Studies on Pyrimidine Derivatives and Related Compounds. LXI. Reaction of Thiamine with Isocyanates. (2)
- Studies on Pyrimidine Derivatives and Related Compounds. LVI. Reaction of Thiamine with Isocyanates. (I)
- Studies on Pyrimidine Derivatives and Related Compounds. LI. Reaction of Thiamine with Amines. (1)
- Studies on Pyrimidine Derivatives and Related Compounds. L. Reactions of Thiamine with Aldehydes
- Synthesis of 4-Hydroperoxy-1,3,2-diazaphosphorinane-2-oxides related to the Activated Cyclophosphamide
- Studies on Pyrimidine Derivatives and Related Compounds. LXXXIII. An Unusual Reaction of Thiamine Ylide with Diaryl Carbodiimide
- An Unusual Heterocyclic Transformation in Liquid Ammonia
- Camphane Derivatives. VII. Syntheses and Structure of 3-Methyl-3aβ, 7aβ-bornano[3,2-d]oxazolidin-2-one and its Derivatives
- Nuclear Magnetic Resonance Studies of Bridged Ring Systems. V. Signals of Methyl Groups in Bornane Derivatives
- Isolation of cis-and trans-2-Methoxymethylene-3-ethoxypropionitrile
- Studies on the Pyrimidine Derivatives and the Related Compounds. XXXVIII. Investigation on 2-Alkoxy-methylene-3-ethoxypropionitrile and Ethyl 2-Alkoxymethylene-3-ethoxypropionate
- New Synthesis of Thiophenes. Use of N-(1,3-Oxathiol-2-ylidene) ternary Iminium Salts
- Syntheses of 1,3-Dithiol-2-ylidene and 1,3-Oxathiol-2-ylidene Derivatives
- Synthesis of N-(1,3-Oxathiol-2-ylidene)ternary Iminium Salts
- Novel Synthesis of Thiophene Derivatives from 1,3-Oxathiol-2-ylideneimmonium Salt
- Physicochemical Properties of 1,3-Dithiol-2-ylidene and 1,3-Oxathiol-2-ylidene Derivatives
- Studies on the Pyrimidine Derivatives. XXX. Syntheses and Reactions of O-(2-Tetrahydropyranyl)-thiamine, O-Tritylthiamine, S-Acylthiamine, and S-Alkoxycarbonylthiamine.
- Syntheses of Pyrazole Derivatives. XI. Acetylation Products of 7-Aminopyrazolo [1,5-a] pyrimidines. Supplement
- Syntheses of Pyrazole Derivatives. IX. Acetylation Products of 7-Aminopyrazolo [1,5-α] pyrimidines
- Studies on the Pyrimidine Derivatives. XXIV. Syntheses of Several Thiol-type Thiamine Derivatives and their Primary Screening Tests.
- Studies on the Pyrimidine Derivatives. XXII. The Syntheses of New Thiamine Derivatives.
- SYNTHESES OF O, S-DICHOLANOYL-THIAMINE DERIVATIVES
- Studies on the Pyrimidine Derivatives. XXI. On the Studies of S-Alkoxycarbonylthiamine. (2).