Studies on Pyrimidine Derivatives and Related Compounds. LIII. The Reaction of Thiamine with Diethyl Acetylphosphonate (Supplement) and the Synthesis of Pseudothiamine

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概要

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• The reaction of deuterioamino-O-acetylthiamine (Id) with dialkyl acetylphosphonate afforded 1-methyl-1-deuterio-3-(2-acetoxy) ethyl-4,9-dimethyl-1,6-dihydropyrimido-[4', 5'-4,5] pyrimido [2,3-c] [1,4] thiazine (IIIf). Treatment of 2-methyl-4-(2-methyl-4-amino-5-pyrimidinyl) methyl-5-methyl-6-(2-acetoxy) ethyl-2H-1,4-thiazin-3 (4H)-one (IVa) with hydrogen peroxide in acetic acid gave 2-acetyl-2-hydroxy-3-(2-methyl-4-amino-5-pyrimidinyl) methyl-4-methyl-5-(2-acetoxy) ethylthiazoline (Va).

• 社団法人日本薬学会の論文
• 1968-09-25

著者

• 高見沢 映

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 佐藤 久夫

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 田中 幸子

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 田中 幸子

  塩野義研究所

• 森 芳夫

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 佐藤 久夫

  塩野義製薬株式会社研究所

• 森 芳夫

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 佐藤 久夫

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

関連論文

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• Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6
• Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).
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