Studies on Pyrimidine Derivatives and Related Compounds. LXI. Reaction of Thiamine with Isocyanates. (2)

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概要

• 論文の詳細を見る

• Thiamine (I) reacted with ethyl isocyanate to give three moles adduct (II) and four moles adduct (III). N-Ethylcarbamoylthiamine (VIII) reacted with ethyl isocyanate to afford a mixture of three moles adducts, and separation of these isomers revealed the formation of perhydrofurothiazole derivatives (IX, X). NaBH_4 reduction of these diastereomers gave dihydro (XIII) and tetrahydro (XV) compounds, respectively.

• 公益社団法人日本薬学会の論文
• 1969-03-25

著者

• 平井 健太郎

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 高見 沢映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 松本 佐市

  Shionogi Research Laboratory, Shionogi and Co., Ltd.

• 石破 暉之

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 松本 佐市

  Shionogi Research Laboratory Shionogi And Co. Ltd.

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