Syntheses of New Cyclophosphamide Derivatives Having 1,3,4,2-Oxadiazaphosphorinane and Related heterocyclic Systems

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概要

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• New cyclophosphamide derivatives having the 1,3,4,2-oxadiazaphosphorinane and related heterocyclic systems were prepared by the ozonolysis reactions of O-(2-propenyl)-and O-(3-butenyl)-N, N-bis(2-chloroethyl) phosphoramidoyl hydrazides and their derivatives. The newly synthesized heterocyclic systems were dihydro-6H-1,3,4,2-oxadiazaphos-phorine-2-oxide, 4-acetyl-5-hydroxy-1,3,4,2-oxadiazaphosphorinane-2-oxide, 4-acetyl-5-hydroxyhexahydro-2H-1,3,4,2-oxadiazaphosphepine-2-oxide and perhydro-1,3,4-oxadiazolo [3,2-c]-1,3,2-oxazaphosphorine-1-oxide. Comparative studies of the in vivo antileukemic activity revealed that these cyclophosphamide derivatives were ineffective in promoting the antitumor action.

• 公益社団法人日本薬学会の論文
• 1977-07-25

著者

• 高見沢 映

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 岩田 豪

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 高見沢 映

  新潟薬科大学

• 牧野 逸男

  塩野義製薬株式会社研究所

• 牧野 逸男

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 酒井 昇二

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 岩田 豪

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 牧野 逸男

  塩野義製薬研究所

• 高見沢 映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 酒井 昇二

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 酒井 昇二

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 松本 佐市

  Shionogi Research Laboratory, Shionogi and Co., Ltd.

• 松本 佐市

  Shionogi Research Laboratory Shionogi And Co. Ltd.

関連論文

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