Studies on Pyrimidine Derivatives and Their Related Compounds. LXXXVI. Unusual Reactions of Thiamine Derivatives
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概要
- 論文の詳細を見る
Reaction of thiamine free base (I) with p-halobenzoyl chloride afforded diacylates (IIb, c) which were hydrolized to give mono-acylates (IIIb, c) under acidic conditions. On the other hand, the reaction of dibenzoate (IIa) and its p-haloanalogues (IIb, c) with triethylamine gave new compounds (IVa, b, c) which are the first examples of thiamine derivatives having a free SH group. The reaction of IVa, b, c with diazomethane afforded S-methyl derivatives (VIa, b, c). The mechanisms of these reactions are discussed as shown in Chart 2.
- 公益社団法人日本薬学会の論文
- 1974-08-25
著者
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高見沢 映
新潟薬科大学
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牧野 逸男
塩野義製薬株式会社研究所
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牧野 逸男
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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牧野 逸男
塩野義製薬研究所
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
関連論文
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