Studies on Pyrimidine Derivatives and Related Compounds. XLIX. Several Reactions of 1-[(2-Methyl-4-amino-5-pyrimidinyl) methyl]-3-alkyl-4-(2-hydroxyethyl)-5-methyl-imidazolium Salts.

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概要

• 論文の詳細を見る

• 1-[(2-Methyl-4-amino-5-pyrimidinyl) methyl]-3-alkyl-4-(2-hydroxyethyl)-5-methylimidazolium salts reacted with diethyl benzoylphosphonate after treatment with triethylamine to give O-benzoate. However, the treatment with dimethylsulfinyl carbanion in dimethylsulfoxide gave iminochrome type compounds (VI, XIX), imidazole (XXVI), and azomethine compounds (VII, XX, XXVIII). The difference of lability between imidazolium and thiazolium C-2 protons was shown by NMR measurements.

• 公益社団法人日本薬学会の論文
• 1967-09-25

著者

• 高見沢 映

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 平井 健太郎

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 松本 至博

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 石破 暉之

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 松本 至博

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 石破 暉之

  Shionogi Research Laboratory Shionogi & Co. Ltd.

関連論文

• Studies on Pyrimidine Derivatives and Related Compounds. LXXV. Reactions of Thiazolium Salts with Diethyl Acylphosphonates and Hydroxylation of Some 3-Oxo-2,3-dihydro-4H-1,4-thiazine Derivatives
• Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6
• Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).
• Studies on the Pyrimidine Derivatives and Related Compounds. XL. Reaction of 3-Benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium Salts with Diethyl Benzoylphosphonate
• Studies on the Pyrimidine Derivatives and Related Compounds. XXXIX. On the Oxidation Products of 2-Pheny1-4-(2-methyl-4-amino-5-pyrimidyl)methyl-5-methyl-6-(2-benzoyloxy or hydroxy)-ethyl-4H-1,4-thiazin-3(2H)-one
• 14.ビタミンB_1関連チアゾール誘導体とDiethylbenzoylphosphonateとの反応(第155回会議研究発表要旨)
• Studies on the Pyrimidine Derivatives. XXVII. A New Method for Synthesis of Diethyl Ethoxycarbonylphosphite from Tris (ethoxythiocarbonyl) Phosphorotrithioite, and on the Reactions of these Organo-phosphorus Compounds with Thiamine Sodium Salt.
• Studies on Pyrimidine Derivatives and Related Compounds. LIII. The Reaction of Thiamine with Diethyl Acetylphosphonate (Supplement) and the Synthesis of Pseudothiamine
• Studies on Pyrimidine Derivatives and Related Compounds. LII. Reaction of Thiamine with Phosphites. (1)
• Studies on the Pyrimidine Derivatives and Related Compounds. XXXV. On the Reaction Product of Thiamine with Diethyl Benzoylphosphonate
• Peptido-aminobenzophenones-Novel Open-ring Derivatives of 1,4-Benzodiazepines
• Interaction of Peptido-aminobenzophenones with Benzodiazepine Receptors
• Studies on Pyrimidine Derivatives and Related Compounds. XCIV. On the Oxidation Products of 2-Substituted-2,3-dihydro-4H-1,4-thiazin-3-one Derivatives. (2)
• On the Reaction of Dialkyl Acylphosphonate with 2-Methyl-1,3,4-thiadiazolium Salts
• On the Reaction of Dialkyl Acylphosphonate with 2-Methylthiazolium Salts
• On the Reactions of 1,3,4-Oxadiazolium Salts with Dialkyl Acylphosphonates. A Novel Synthesis of 1,3,4-Oxadiazin-5-one Derivatives
• Studies on Pyrimidine Derivatives and Related Compounds. LXXXVII. Reaction of Thiamine Analogues with Diethyl Benzoylphosphonate
• On the Reactions of Oxazolium Salts with Dialkyl Acylphosphonates. A Novel Synthesis of 1,4-Oxazin-3-one and Azetidin-2-one Derivatives
• Studies on Pyrimidine Derivatives and Related Compounds. LXXVII. Reaction of Thiamine Analogues with Diethyl Benzoylphosphonate
• Studies on Pyrimidine Derivatives and Related Compounds. LXXIII. Syntheses and Reactions of Thiamine Sulfur Analogues and Related Derivatives. (2)
• Studies on Pyrimidine Derivatives and Related Compounds. LXXII. Syntheses and Reactions of Thiamine Sulfur Analogues and Related Derivatives. (1)
• Studies on Pyrimidine Derivatives and Related Compounds. LXXI. Reaction of Thiamine Anhydride with Thiols
• Studies on Pyrimidine Derivatives and Related Compounds. LXX. A Novel Reaction of Thiamine Anhydride
• Studies on Pyrimidine Derivatives and Related Compounds. LXIX. Sythesis of Thiamine Free Base
• Studies on Pyrimidine Derivatives and Related Compounds. LXVIII. Reactions of Dialkyl Acylphosphonates with 1,3-Disubstituted Benzimidazolium Halides
• Studies on Pyrimidine Derivatives and Related Compounds. LXVII. Reaction of Thiadiazolium Derivatives with Dialkyl Acylphosphonates
• Studies on Pyrimidine Derivatives and Related Compounds. LXVI. Reactions of Dialkyl Acylphosphonates with 1,3,4-Thiadiazolium Derivatives
• Investigation on the Reaction of Benzazolium Salts with Base
• Synthesis and Reactions of Thiamine Disulfide sulfur Analogues
• Studies on Pyrimidine Derivatives and Related Compounds. LIX. Syntheses of 2,3-Dihydro-1H-pyrazolo [5,1-b] purin-2-ones
• Synthesis and Reactions of Thiaminedisulfide Sulfur Derivatives
• Reactions of 2-Dialkylamino-5-phenyl-1,3-oxathiolium Cation with Nucleophiles Containing an Amino Group
• Syntheses of 2-Disubstituted-amino-4-arylthiazol-5-ylalkanoic Acids
• Studies on the Urinary Metabolites of Isophosphamide and Its Activated Species in Rabbits
• Synthesis, Stereochemistry and Antitumor Activity of 4-Hydroperoxyiso-phosphamide (NSC-227114) and Related Compounds
• Syntheses of New Cyclophosphamide Derivatives Having 1,3,4,2-Oxadiazaphosphorinane and Related heterocyclic Systems
• Addition Reaction of 3-Substituted-4-methyl-5- (2-hydroxy) ethyl-thiazolium Salt with Diaryl Carbodiimide
• Studies on Pyrimidine Derivatives and Related Compounds. LXXXI. Reactions of Aryl Isothiocyanates with Thiamine and Related Thiazolium Ylides
• Studies on Pyrimidine Derivatives and Related Compounds. LXII. Cycloadditions of Alkyl Isothiocyanates with Thiamine and Related Thiazolium Ylids and Facile Conversions of the Adducts to Dihydroimidazo [4,5-d] thiazole Derivatives
• Studies on Pyrimidine Derivatives and Related Compounds. LX. Synthesis of Hydroxymethylthiamine
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• ビタミンB研究委員会第230回会議研究発表要旨
• 7.O-Tetrahydropyranyl-S-alkoxycar-bonylthiamineの製法について(第143回会議研究発表要旨)
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• Studies on Pyrimidine Derivatives and Related Compounds. XLIX. Several Reactions of 1-[(2-Methyl-4-amino-5-pyrimidinyl) methyl]-3-alkyl-4-(2-hydroxyethyl)-5-methyl-imidazolium Salts.
• Studies on Pyrimidine Derivatives and Related Compounds. XLIV. Syntheses of Thiazolo [3,2-a] pyrimidine Derivatives
• 40.ピリミジン誘導体および関連化合物の研究(LV) : S-AlkoxycarbonylthiamineおよびDisulfide型ビタミンB_1誘導体の合成(補遺)(第18回大会研究発表要旨)
• 39.ピリミジン誘導体および関連化合物の研究(LIV) : Dicarbethoxythiamineの一新全合成法(第18回大会研究発表要旨)
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• Synthese of 4-Aryliminoparabanic Acids and 2-Arylimino-2,3-dihydro-1,4-thiazine Derivatives via 2-N, N'-Diarylamidinothiazolium Salts
• Studies on Pyrimidine Derivatives and Related Compounds. LXXX. Unusual Reactions of Thiamine Free Base with Electrophilic Reagents. (2)
• Studies on Pyrimidine Derivatives and Their Related Compounds. LXXVIII. Unusual Reactions of Thiamine Free Base with Some Electrophilic Reagents
• Studies on Pyrimidine Derivatives and Related Compounds. XLV. On Some Synthetic Methods of N-[1-(2-Oxo-1,3-oxathian-4-ylidene) ethyl]-N-[(2-methyl-4-amino-5-pyrimidinyl)-methyl] formamide
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• Studies on Pyrimidine Derivatives and Related Compounds. LI. Reaction of Thiamine with Amines. (1)
• Studies on Pyrimidine Derivatives and Related Compounds. L. Reactions of Thiamine with Aldehydes
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• Nuclear Magnetic Resonance Studies of Bridged Ring Systems. V. Signals of Methyl Groups in Bornane Derivatives
• Isolation of cis-and trans-2-Methoxymethylene-3-ethoxypropionitrile
• Studies on the Pyrimidine Derivatives and the Related Compounds. XXXVIII. Investigation on 2-Alkoxy-methylene-3-ethoxypropionitrile and Ethyl 2-Alkoxymethylene-3-ethoxypropionate
• New Synthesis of Thiophenes. Use of N-(1,3-Oxathiol-2-ylidene) ternary Iminium Salts
• Syntheses of 1,3-Dithiol-2-ylidene and 1,3-Oxathiol-2-ylidene Derivatives
• Synthesis of N-(1,3-Oxathiol-2-ylidene)ternary Iminium Salts
• Novel Synthesis of Thiophene Derivatives from 1,3-Oxathiol-2-ylideneimmonium Salt
• Physicochemical Properties of 1,3-Dithiol-2-ylidene and 1,3-Oxathiol-2-ylidene Derivatives
• Studies on the Pyrimidine Derivatives. XXX. Syntheses and Reactions of O-(2-Tetrahydropyranyl)-thiamine, O-Tritylthiamine, S-Acylthiamine, and S-Alkoxycarbonylthiamine.
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• Studies on the Pyrimidine Derivatives. XXII. The Syntheses of New Thiamine Derivatives.
• SYNTHESES OF O, S-DICHOLANOYL-THIAMINE DERIVATIVES
• Studies on the Pyrimidine Derivatives. XXI. On the Studies of S-Alkoxycarbonylthiamine. (2).

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